Abstract
From the diacylglycerol acyltransferase (DGAT) activity-guided fractionation, a new quinolone alkaloid, 1-methyl-2-tetradecyl-4(1H)-quinolone (1) was isolated from the fruits of Evodia rutaecarpa together with three known quinolone alkaloids, evocarpine (2), 1-methyl-2-[(4Z,7Z)-4,7-decadienyl]-4(1H)-quinolone (3) and 1-methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone (4). They showed a dose-dependent DGAT inhibition with IC50 values of 69.5 μM (1), 23.8 μM (2), 20.1 μM (3) and 13.5 μ (4) .
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Hyun Sun Lee Ph. D.
Laboratory of Lipid Metabolism
Korea Research Institute of Bioscience and Biotechnology
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