Zusammenfassung
Es wurde die NK-Stimulation bei 73 Patienten einer immunologischen Schwerpunktpraxis vor Therapiebeginn mit verschiedenen Immunmodulatoren in vitro untersucht. Die in vitro Stimulation mit Acetylsalicylsäure erfolgte bei 52 Patienten. Sie führte zu einer hochsignifikanten (p < 0,01) Verbesserung der NK-Zell-Aktivität in vitro. Acetylsalicylsäure stimulierte die NK-Zell-Aktivität im Vergleich zu Salicin in vitro signifikant stärker (p = 0,013).
Bei 11 Patienten erfolgte Kontrolle der basalen (nicht stimulierten) NK-Zellaktivität nach 12 Wochen Therapie mit 100 mg Acetylsalicylsäure (Aspirin® protect 100). Bei diesen Patienten konnte eine signifikante Steigerung (p = 0,013) der posttherapeutischen basalen NK-Zell-Aktivität beobachtet werden.
Summary
73 patients from a medical practice were examined by means of an in vitro NK-cell stimulation test prior to immunomodulatory therapy. In vitro-NK-cell stimulation was tested in 52 Patients by aspirin supplementation. Aspirin® protect augmented NK-cell stimulation significantly (p < 0,01) and effects were stronger compared to salicin (p < 0,01). 11 Patients showed an improvement of their basic NK-cell activity after treatment with low-dose aspirin® protect (100 mg/d) over a 12 week period (p = 0,013).
Schlüsselwörter
NK-Zellen - in vitro-Stimulation - NK-Stimulation durch Acetylsalicylsäure
Keywords
NK-cells - in vitro NK-cell stimulation - NK-cell stimulation by acetylsalicylic acid
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