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Semin Thromb Hemost 2002; 28(6): 529-532
DOI: 10.1055/s-2002-36696
Copyright © 2002 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Influence of Low- and High-Molecular-Weight Plasminogen Activators on the Onset of Labor and on the Hemostatic System

Takanori Moriyama1 , Shigenori Suzuki2 , Kazuhiko Matsuno1 , Kiyotaka Okada3 , Osamu Matsuo3
  • 1Department of Laboratory Technology, College of Medical Technology, Hokkaido University, Sapporo, Japan
  • 2College of Medical Technology, Hokkaido University, Sapporo, Japan
  • 3Department of Physiology, Kinki University School of Medicine, Osakasayama, Japan
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Publikationsdatum:
21. Januar 2003 (online)

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ABSTRACT

Measurement of activities of urinary (u-PA) and tissue plasminogen activator (t-PA) and analysis of euglobulin lysis times (ELTs) and prekallikrein were performed simultaneously using the plasma of normal pregnant women and nonpregnant women. The activities of plasminogen activators were determined by the method of electrophoretic zymography. The activity of low-molecular-weight (LMW) u-PA was significantly decreased at the onset of labor (p = 0.05) compared with that during the latter half of pregnancy. The same tendency was observed in the analysis of prekallikrein. On the contrary, no significance was shown in activities of high-molecular-weight (HMW) u-PA or t-PA. It is suggested that the action of kallikrein on low-molecular-weight u-PA causes it to change into plasmin at the onset of labor.

KEYWORD

Tissue-type plasminogen activator (t-PA) - urinary plasminogen activator (u-PA) - zymography - hemostasis - onset of labor

REFERENCES

  • 1 Suzuki S, Morishita S. The relationship between the onset of labor mechanisms and the hemostatic system.  Immunopharmacology . 1999;  43 133-140
    CrossrefPubMedSuche in Google Scholar
  • 2 Matsuo O, Sakai T, Okada K. Plasminogen activator in bronchoalveolar fluid.  Haemostasis . 1986;  16 43-50
    PubMedSuche in Google Scholar
  • 3 Bachmann F. Plasminogen activators. In: Colman RW, Hirsh J, Marder VJ, Salzman EW, eds. Hemostasis and Thrombosis: Basic Principles and Clinical Practice, 2nd ed Philadelphia, PA: JB Lippincott 1987: 318-338
    Suche in Google Scholar
  • 4 Gaffney P J. Fibrinolysis. In: Bloom AL, Thomas DP, eds. Haemostasis and Thrombosis, 2nd ed London, UK: Churchill Livingstone 1987: 223-244
    Suche in Google Scholar