ABSTRACT
A number of drugs, either physician prescribed or those taken without the knowledge
of the physician, may have metabolic effects on, and result in abnormal changes in,
the musculoskeletal system. These medications may involve the developing fetus, infant,
child, or adult and may manifest as drug-induced embryopathies, osteoporosis, osteomalacia,
or rickets, or a combination of these, or they may be associated with proliferative
changes. Not uncommonly, the radiologist may be the first physician to identify the
metabolic manifestations of these medications. The radiological changes associated
with such drugs will be reviewed. Certain drugs may have teratogenic effects, nonteratogenic
effects, or both. These effects, dependent solely on the timing of administration,
will be discussed separately.
KEYWORD
Congenital abnormality,osteoporosis - rickets - osteomalacia - periostitis - proliferative
enthesopathy
