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Semin Musculoskelet Radiol 2002; 06(4): 285-298
DOI: 10.1055/s-2002-36727
Copyright © 2002 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Drug-Induced Metabolic Bone Disorders

Jack Lawson
  • Department of Radiology, Yale University School of Medicine, New Haven, Connecticut
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Publication History

Publication Date:
22 January 2003 (online)

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ABSTRACT

A number of drugs, either physician prescribed or those taken without the knowledge of the physician, may have metabolic effects on, and result in abnormal changes in, the musculoskeletal system. These medications may involve the developing fetus, infant, child, or adult and may manifest as drug-induced embryopathies, osteoporosis, osteomalacia, or rickets, or a combination of these, or they may be associated with proliferative changes. Not uncommonly, the radiologist may be the first physician to identify the metabolic manifestations of these medications. The radiological changes associated with such drugs will be reviewed. Certain drugs may have teratogenic effects, nonteratogenic effects, or both. These effects, dependent solely on the timing of administration, will be discussed separately.

KEYWORD

Congenital abnormality,osteoporosis - rickets - osteomalacia - periostitis - proliferative enthesopathy

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