Subscribe to RSS
DOI: 10.1055/s-2002-38243
Aortic Carboxypeptidase-Like Protein (ACLP): What is a Protein with a Name Like That Doing in Adipose Tissue?
Publication History
Received 4 October 2002
Accepted after revision 19 November 2002
Publication Date:
27 March 2003 (online)
Introduction
Aortic carboxypeptidase-like protein (ACLP) was originally cloned from aortic vascular smooth-muscle cells. It has been chosen as a subject for a hypothesis paper in this current issue of the journal due to its recent identification as a protein that is also expressed in adipose cells. Current data indicate its expression is downregulated during the early phase of the differentiation of fibroblast-like preadipose cells into mature adipose cells (adipogenesis). Remodeling the extracellular matrix (ECM) is a critical early event in adipogenesis, and ACLP may have the potential to interact with matrix components.
References
- 1 Layne M D, Endege W O, Jain M K, Yet S-F, Hsieh C-M, Chin M T. et al . Aortic carboxypeptidase-like protein, a novel protein with discoidin and carboxypeptidase-like domains, is up-regulated during vascular smooth muscle cell differentiation. J Biol Chem. 1998; 273 15 654-15 660
- 2 Novikova E G, Reznik S E, Varlamov O, Fricker L D. Carboxypeptidase Z is present in the regulated secretory pathway and extracellular matrix in cultured cells and in human tissues. J Biol Chem. 2000; 275 4865-4870
- 3 Layne M D, Yet S-F, Maemura K, Hsieh C-M, Bernfield M, Perrella M A. et al . Impaired abdominal wall development and deficient wound healing in mice lacking aortic carboxypeptidase-like protein. Mol Cell Biol. 2001; 21 5256-5261
- 4 Vogel W, Gish G D, Alves F, Pawson T. The discoidin domain receptor tyrosine kinases are activated by collagen. Mol Cell. 1997; 1 13-23
- 5 Shrivastava A, Radziejewski C, Campbell E, Kovac L, McGlynn M, Ryan T E. et al . An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors. Mol Cell. 1997; 1 25-34
- 6 He G-P, Muise A, Li A W, Ro H-S. A eukaryotic transcriptional repressor with carboxypeptidase activity. Nature. 1995; 378 92-96
- 7 Song L, Fricker L D. Cloning and expression of human carboxypeptidase Z, a novel metallocarboxypeptidase. J Biol Chem. 1997; 272 10 543-10 550
- 8 Ro H-S, Kim S-W, Wu D, Webber C, Nicholson T E. Gene structure and expression of the mouse adipocyte enhancer-binding protein. Gene. 2001; 280 123-133
- 9 Rosen E D, Walkey C J, Puigserver P, Spiegelman B M. Transcriptional regulation of adipogenesis. Genes Dev. 2000; 14 1293-1307
- 10 Soukas A, Socci N D, Saatkamp B D, Novelli S, Friedman J M. Distinct transcriptional profiles of adipogenesis in vivo and in vitro. J Biol Chem. 2001; 276 34 167-34 174
- 11 Ross S E, Erickson R L, Gerin I, DeRose P M, Bajnok L, Longo K A. et al . Microarray analyses during adipogenesis: Understanding the effects of Wnt signaling on adipogenesis and the roles of liver X receptor a in adipocyte metabolism. Mol Cell Biol. 2002; 22 5989-5999
- 12 Hauner H, Skurk T, Wabitsch M. Cultures of human adipose precursor cells. Methods Mol Biol. 2001; 155 239-247
- 13 Gregoire F M, Smas C M, Sul H S. Understanding adipocyte differentiation. Physiol Rev. 1998; 78 783-809
- 14 Lin F-T, Lane M D. CCAAT/enhancer binding protein a is sufficient to initiate the 3T3-L1 adipocyte differentiation program. Proc Natl Acad Sci USA. 1994; 91 8757-8761
- 15 Shao D, Lazar M A. Peroxisome proliferator activated receptor g, CCAT/Enhancer-binding protein a, and cell cycle status regulate the commitment to adipocyte differentiation. J Biol Chem. 1997; 272 21 473-21 478
- 16 El-Jack A K, Hamm J K, Pilch P F, Farmer S R. Reconstitution of insulin-sensitive glucose transport in fibroblasts requires expression of both PPARg and C/EBPa. J Biol Chem. 1999; 274 7946-7951
- 17 Wu Z, Rosen E D, Brun R, Hauser S, Adelmant G, Troy A E. et al . Cross-regulation of C/EBPa and PPARg controls the transcriptional pathway of adipogenesis and insulin sensitivity. Mol Cell. 1999; 3 151-158
- 18 Qiu Z, Wei Y, Chen N, Jiang M, Wu J, Liao K. DNA synthesis and mitotic clonal expansion is not a required step for 3T3-L1 preadipocyte differentiation into adipocytes. J Biol Chem. 2001; 276 11 988-11 995
- 19 Hauner H. Complete adipose differentiation of 3T3-L1 cells in a chemically defined medium: comparison to serum-containing culture conditions. Endocrinology. 1990; 127 865-872
- 20 Kuri-Harcuch W, Marsch-Moreno M. DNA synthesis and cell division related to adipose differentiation of 3T3 cells. J Cell Physiol. 1983; 114 39-44
- 21 Yeh W-C, Bierer B E, McKnight S L. Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells. Proc Natl Acad Sci USA. 1995; 92 11 086-11 090
- 22 Gagnon A, Abbaiian K J, Crapper T, Layne M D, Sorisky A. Down-regulation of aortic carboxypeptidase-like protein during the early phase of 3T3-L1 adipogenesis. Endocrinology. 2002; 143 2478-2485
- 23 Richon V M, Lyle R E, McGehee R E. Regulation and expression of retinoblastoma proteins p107 and p130 during 3T3-L1 adipocyte differentiation. J Biol Chem. 1997; 272 10 117-10 124
- 24 Springer W R, Cooper D N, Barondes S H. Discoidin I is implicated in cell-substratum attachment and ordered cell migration of Dictyostelium and resembles fibronectin. Cell. 1984; 39 557-564
- 25 Spiegelman B M, Ginty C A. Fibronectin modulation of cell shape and lipogenic gene expression in 3T3-adipocytes. Cell. 1983; 35 657-666
- 26 Ignotz R A, Massague J. Type b transforming growth factor controls the adipogenic differentiation of 3T3 fibroblasts. Proc Natl Acad Sci USA. 1985; 82 8530-8534
- 27 Gagnon A M, Chabot J, Pardasani D, Sorisky A. Extracellular matrix induced by TGFb impairs insulin sugnal transduction in 3T3-L1 preadipose cells. J Cell Physiol. 1998; 175 370-378
- 28 Saltiel A. You are what you secrete. Nature Med. 2001; 7 887-888
- 29 Kratchmarova I, Kalume D E, Blagoev B, Scherer P E, Podtelejnikov A V, Molina H. et al . A proteomics approach for identification of secreted proteins during the differentiation of 3T3-L1 preadipocytes to adipocytes. Mol Cell Proteomics. 2002; 1 213-222
Dr. A. Sorisky
Ottawa Health Research Institute
725 Parkdale Avenue · Ottawa ON K1Y 4E9 Canada ·
Phone: +1 (613) 798-5555 #17572
Fax: +1 (613) 761-5036
Email: asorisky@ohri.ca