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Synthesis 2003(1): 0019-0020
DOI: 10.1055/s-2003-36252
DOI: 10.1055/s-2003-36252
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York
A Direct Introduction of the Mercaptoacetic Acid Unit into Amino Acid Esters
Further Information
Received
1 August 2002
Publication Date:
18 December 2002 (online)
Publication History
Publication Date:
18 December 2002 (online)
Abstract
The reaction of amino acid esters with 1,3-oxathiolan-5-one 1a provided thiol amides 3.
Key words
combinatorial chemistry - amino acids - amines - ligands - thiols - acylations - esters
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1a
Baidoo KE.Lever SZ. Bioconjugate Chem. 1990, 1: 132 -
1b
Bryson N.Dewan JC.Lister-James J.Jones AG.Davison A. Inorg. Chem. 1988, 27: 2154 - 2
Bell RA.Dickson KC.Valliant JF. Can. J. Chem. 1999, 77: 146 - 3
Higashiya S.Narizuka S.Konno A.Maeda T.Momota K.Fuchigami T. J. Org. Chem. 1999, 64: 133 - 4
Molt KR,Hechenbleikner I, andHomberg O. inventors; A U.S. 3305573. The diphenylsilyl analog has been reported: -
5a Compound 3a:
Johannsen B.Noll B.Leibnitz G.Reck G.Noll St.Spies H. Radiochim. Acta 1993, 63: 133 -
5b Compound 3d:
Davidovich YA.Semenova NN.Babievskii KK.Rogozhin SV. Izv. Akad. Nauk., Ser. Khim. 1986, 2139 - 6 MTPA ester:
Dale JA.Mosher HS. J. Am. Chem. Soc. 1973, 95: 512