Synlett 2003(2): 0250-0252
DOI: 10.1055/s-2003-36796
LETTER
© Georg Thieme Verlag Stuttgart · New York

Novel Microwave-assisted [3+3] Cyclocondensations with 1-Cyanomethylene Tetrahydroisoquinoline

Péter Nemes*a, Zoltán Vinczea, Barbara Balázsb, Gábor Tóthb, Pál Scheibera
a Department of Chemistry, Faculty of Veterinary Science, Szent István University, H-1400 Budapest, P.O.Box 2, Hungary
Fax: 36(1)478 4268; e-Mail: pnemes@univet.hu;
b Technical Analytical Research Group, Institute for General and Analytical Chemistry, Technical University, H-1111 Budapest, Szent Gellért tér 4, Hungary
Further Information

Publication History

Received 31 October 2002
Publication Date:
22 January 2003 (online)

Zoom Image

Abstract

α,β-Unsaturated aldehydes and ketones react with 1-cyanomethylene-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline in microwave-enhanced reactions affording regioselectively 6,7-dihydro-4H-benzo[a]quinolizines and 6,7-dihydro-2H-benzo[a]quinolizines, respectively.