The use of titanium(IV) chloride as a Lewis acid for direct ortho-acylation
of phenols and naphthols proves to be a convenient, more general
and direct route to various hydroxyaryl ketones. The route is regioselective,
leading to ortho C-acylated products
in satisfactory to high yields in most cases.
ortho-acylation - Lewis acid - electrophilic
substitution - hydroxyaryl ketone - regioselectivity
