Planta Med 2003; 69(1): 89-91
DOI: 10.1055/s-2003-37022
Letter
© Georg Thieme Verlag Stuttgart · New York

Polymeric Proanthocyanidins from the Bark of Hamamelis virginiana

A. Dauer1 , H. Rimpler2 , A. Hensel1
  • 1Hochschule Wädenswil, University of Applied Sciences, Pharmaceutical Biotechnology, Wädenswil, Switzerland
  • 2University of Freiburg, Institute of Pharmaceutical Biology, Freiburg, Germany
Further Information

Publication History

Received: May 10, 2002

Accepted: July 13, 2002

Publication Date:
04 February 2003 (online)

Abstract

Polymeric proanthocyanidins were isolated from the bark of Hamamelis virginiana L. in yields of about 5 %. Fractionation yielded fractions with similar structures but different molecular weights with DP between 17 - 29 (thiolysis) and 11 - 20 (GPC). Polymers were composed predominantly of epicatechin and epigallocatechin as chain extension units at ratio of about 1.3 : 1. Terminal chain units were catechin (∼ 95 %) and gallocatechin (∼ 5 %). All chain extension units were completely galloylated at position O-3, while chain terminating units were not galloylated. Predominant interflavan linkages were 4 → 8-bonds.

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PD Dr. A. Hensel

Hochschule Wädenswil

University of Applied Sciences

Pharmaceutical Biotechnology

Gruental

CH-8820 Wädenswil

Switzerland

Phone: +41-1789 9670

Fax: +41-1789 9950

Email: a.hensel@hswzfh.ch