Inhibition of 5α-Reductase Activity by Diarylheptanoids from Alpinia officinarum

Abstract

The acetone extract from the rhizomes of Alpinia officinarum was evaluated for activity against 5α-reductase which had been prepared from rat prostate. The fraction responsible for the inhibition of the enzyme was purified, analyzed, and the active constituents were identified as four diarylheptanoids, 1,7-diphenylhept-4-en-3-one, dihydroyashabushiketol (1,7-diphenyl-5-hydroxy-3-heptanone), 5-hydroxy-7-(4″-hydroxy-3″-methoxyphenyl)-1-phenyl-3-heptanone and 5-hydroxy-7-(4″-hydroxyphenyl)-1-phenyl-3-heptanone.

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