Planta Med 2003; 69(1): 72-74
DOI: 10.1055/s-2003-37028
Letter
© Georg Thieme Verlag Stuttgart · New York

Inhibition of 5α-Reductase Activity by Diarylheptanoids from Alpinia officinarum

Yong-ung Kim1 , Hyun Kyong Son1 , Hye Kyoung Song1 , Mi-Jeong Ahn1 , Sang Sup Lee1 , Seung Ki Lee1
  • 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea
Further Information

Publication History

Received: April 30, 2002

Accepted: August 13, 2002

Publication Date:
04 February 2003 (online)

Abstract

The acetone extract from the rhizomes of Alpinia officinarum was evaluated for activity against 5α-reductase which had been prepared from rat prostate. The fraction responsible for the inhibition of the enzyme was purified, analyzed, and the active constituents were identified as four diarylheptanoids, 1,7-diphenylhept-4-en-3-one, dihydroyashabushiketol (1,7-diphenyl-5-hydroxy-3-heptanone), 5-hydroxy-7-(4″-hydroxy-3″-methoxyphenyl)-1-phenyl-3-heptanone and 5-hydroxy-7-(4″-hydroxyphenyl)-1-phenyl-3-heptanone.

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Prof. Dr. Seung Ki Lee

College of Pharmacy

Seoul National University

San 56-1

Sillim-dong

Gwanak-gu

Seoul 151-742

Republic of Korea

Fax: 82-2-889-0751

Email: sklcrs@plaza.snu.ac.kr