Planta Med 2003; 69(1): 94-96
DOI: 10.1055/s-2003-37031
Letter
© Georg Thieme Verlag Stuttgart · New York

A New Diepoxy-ent-kauranoid, Rugosinin, from Isodon rugosus

Ahmed Abbaskhan1 , M. Iqbal Choudhary1 , Yoshisuke Tsuda1 , Masood Parvez2 ,  Atta-ur-Rahman1 , Farzana Shaheen1 , Zeba Parween1 , Rasool Baksh Tareen3 , Mudassir Asrar Zaidi3
  • 1H. E. J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi, Pakistan
  • 2Department of Chemistry, Faculty of Science, University of Calgary, Calgary, Alberta, Canada
  • 3Department of Botany, University of Balochistan, Quetta, Pakistan
Further Information

Publication History

Received: May 3, 2002

Accepted: August 13, 2002

Publication Date:
29 April 2004 (online)

Abstract

A new diterpenoid, rugosinin (1), isolated from Isodon rugosus, with absolute configuration was proved by single-crystal X-ray diffraction analysis, to be the member of a rare class of C-20/C-7 and C-20/C-14 diepoxy-ent-kauranoids. Effusanin A (2), effusanin B (3), effusanin E (4), lasiokaurin (5) and oridonin (6) were found as known constituents of the genus Isodon with C-20/C-7 epoxy function. These compounds have exhibited DNA-damaging activity in assay which employed DNA-repair deficient (RAD 52Y) and repair proficient (RAD+) yeast strains.

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Prof. Dr. M. Iqbal Choudhary

H.E.J. Research Institute of Chemistry

International Center for Chemical Sciences

University of Karachi

Karachi-75270, Pakistan

Fax: (+92)-21-924-3190

Phone: (+92)-21-924-3224.

Email: zainraa@digicom.net.pk.