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Planta Med 2003; 69(1): 75-77
DOI: 10.1055/s-2003-37042
Letter
© Georg Thieme Verlag Stuttgart · New York

The Vasorelaxant Activity of Marrubenol and Marrubiin from Marrubium vulgare

Sanae El Bardai2, 3 , Nicole Morel2 , Maurice Wibo2 , Nicolas Fabre1 , Gabriel Llabres4 , Badiaa Lyoussi3 , Joëlle Quetin-Leclercq1
  • 1Laboratoire de Pharmacognosie, Université catholique de Louvain, Brussels, Belgium
  • 2Laboratoire de Pharmacologie, Université catholique de Louvain, Brussels, Belgium
  • 3UFR Physiologie-Pharmacologie, Faculté des Sciences Dahar-Elmahraz, Fes, Morocco
  • 4Département de Physique Expérimentale, Université de Liège, Liège, Belgium
Further Information

Publication History

Received: April 25, 2002

Accepted: September 22, 2002

Publication Date:
04 February 2003 (online)

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Abstract

Crude extracts of the aerial parts of Marrubium vulgare show a potent in vitro inhibition of KCl-induced contraction of rat aorta. Bio-guided fractionations, spectroscopic analysis and chemical derivatization revealed the furanic labdane diterpenes marrubenol and marrubiin as the most active compounds.

References

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N. Morel

Laboratoire de Pharmacologie

Université catholique de Louvain

UCL 5410

Avenue Hippocrate 54

1200 Brussels

Belgium

Phone: +32-2-764-5377

Fax: +32-2-764-5460

Email: Morel@farl.ucl.ac.be