Planta Med 2003; 69(2): 167-170
DOI: 10.1055/s-2003-37708
Letter
© Georg Thieme Verlag Stuttgart · New York

Cytotoxic Activity of Natural Labdanes and their Semi-Synthetic Modified Derivatives from Croton oblongifolius

Damrong Sommit1 , Amorn Petsom1 , Tsutomu Ishikawa2 , Sophon Roengsumran1
  • 1Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand
  • 2Faculty of Pharmaceutical Science, Chiba University, Inage, Chiba, Japan
Further Information

Publication History

Received: May 14, 2002

Accepted: October 3, 2002

Publication Date:
07 March 2003 (online)

Abstract

Labda-7,12(E),14-triene-17-oic acid, previously isolated from Croton oblongifolius, and its derivatives were investigated for cytotoxicity against five human tumor cell lines. Six of these compounds, labda-7,12(E),14-triene-17-al, 17-hydroxylabda-7,12(E),14-triene, 17-acetoxylabda-7,12(E),14-triene, 15-hydroxylabda-7,13(E)-diene-17,12-olide, labda-7,13(E)-diene-17,12-olide, and 12,17-dihydroxylabda-7,13(E)-diene showed non-specific, moderate, cytotoxicity against all cell lines, whereas the other compounds were inactive.

References

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Dr. Sophon Roengsumran

Department of Chemistry

Faculty of Science

Chulalongkorn University

Phayathai Rd.

Pathumwan

Bangkok 10330

Thailand

Fax: +66-2-253-0321

Email: amorn.p@chula.ac.th