Abstract
Two new protopine-type alkaloids, argemexicaine A (1) and argemexicaine B (2), along with thirteen known alkaloids, were isolated from MeOH extracts of Formosan
Argemone mexicana L. (Papaveraceae). Physical and spectral analyses, particularly IR and thermo-modulated
1D and 2D NMR, were used to determine the transannular conformations of the isolated
protopine-type alkaloids. The known benzo[c]phenanthridine (±)-6-acetonyldihydrochelerythrine (5) exhibited significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therapeutic Index) values of 1.77 μg/mL and 14.6, respectively.
Key words
Argemone mexicana
- Papaveraceae - argemexicaine A - argemexicaine B - protopine - benzo[c]phenanthridine
- (±)-6-acetonyldihydrochelerythrine - anti-HIV activity
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Prof. Dr. Yang-Chang Wu
Graduate Institute of Natural Products
Kaohsiung Medical University
Kaohsiung 807
Taiwan
Republic of China
Email: yachwu@kmu.edu.tw
Fax: +886-7-3114773
