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DOI: 10.1055/s-2003-37716
Coumarins and Carbazoles from Clausena excavata Exhibited Antimycobacterial and Antifungal Activities
Publication History
Received: June 4, 2002
Accepted: October 27, 2002
Publication Date:
07 March 2003 (online)


Abstract
Four known coumarins, dentatin (1), nor-dentatin (2), clausenidin (3) and xanthoxyletin (5), and six known carbazole derivatives, 3-formylcarbazole (6), mukonal (7), 3-methoxycarbonylcarbazole (8), murrayanine (9), 2-hydroxy-3-formyl-7-methoxycarbazole (10) and clauszoline J (11) were isolated from Clausena excavata. Compounds 1 and 6 were first isolated from the crude chloroform extract of the rhizomes. Compounds 1, 2, 3, 6, 7, 8, 10 and 11 showed antimycobacterial activity at a minimum inhibitory concentration (MIC) of 50, 100, 200, 100, 200, 50, 100 and 100 μg/mL, respectively. O-Methylated clausenidin (4), prepared from 3, exhibited antimycobacterial activity at MIC 50 μg/mL. Compounds 6, 7, 8 and 10 showed antifungal activity with IC50 values of 13.6, 29.3, 9.5 and 2.8 μg/mL, respectively. All compounds demonstrated no cytotoxicity against KB and BC-1 cell lines.