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Planta Med 2003; 69(2): 179-181
DOI: 10.1055/s-2003-37717
DOI: 10.1055/s-2003-37717
Letter
© Georg Thieme Verlag Stuttgart · New York
Vasorelaxing Properties and Bio-Guided Fractionation of Cedrelopsis grevei
Further Information
Publication History
Received: May 17, 2002
Accepted: November 16, 2002
Publication Date:
07 March 2003 (online)
![](https://www.thieme-connect.de/media/plantamedica/200302/lookinside/thumbnails/10.1055-s-2003-37717-1.jpg)
Abstract
The activity-guided fractionation of the hydroalcoholic extract of trunk bark of Cedrelopsis grevei led to the isolation of five coumarins, norbraylin (1), methyl-O-cedrelopsin (2), cedrecoumarin A (3), scoparone (4) and braylin (5) as a part of the constituents responsible for the vasorelaxing activity observed for the crude extract.
References
- 1 Boiteau P, Allorge-Boiteau L. Plantes médicinales de Madagascar. Ed. ACTT, ICSN (Karthala). 1997
- 2 Eshiett I T, Taylor D AH. The isolation and structure elucidation of some derivatives of dimethyl-allyl-coumarin, chromone, quinoline and phenol from Fagara species and from Cedrelopsis grevei . J Chem Soc Sect C 1968: 481-4
- 3 Schulte K E, Rücker G, Klewe U. Some constituents of the bark of Cedrelopsis grevei Baillon. Arch Pharm (Weinheim). 1973; 306 857-65
- 4 Dean F M, Robinson M L. The heartwood chromones of Cedrelopsis grevei . Phytochemistry. 1971; 10 3221-7
- 5 Mulholland D A, Mahomed H A, Kotsos M P, Randrianarivelojosia M , Lavaud C, Massiot G, Nuzillard J M. Limonoid derivatives from Cedrelopsis grevei . Tetrahedron. 1999; 55 11 547-52
- 6 Koorbanally N A, Randrianarivelojosia M, Mulholland D A, Ufford L Q, Berg A JJ. Bioactive Constituents of Cedrelopsis microfoliata . J Nat Prod. 2002; 65 1349-52
- 7 Herz W, Bhat S V, Santhanam P S. Coumarins of Artemisia dracunculoides and 3′,6-dimethoxy-4′,5,7-trihydroxyflavone in Artemisia artica . Phytochemistry. 1970; 9 891-4
- 8 Huei-Chen H, Chai-Rong L, Yu-I W, Ming-Chih L, Yuan-The L. Vasodilator effect of scoparone (6,7-dimethoxycoumarin) from a Chinese herb. Eur J Pharmacol. 1992; 218 123-8
- 9 Deshmukh M N, Deshpande V H, Rama Rao A V. Two new coumarins from Toddalia aculeata . Phytochemistry. 1976; 15 1419-20
- 10 Toro M JU, Müller A H, Arruda M SP, Arruda A C. Alkaloids and coumarins from Ticorea longiflora . Phytochemistry. 1997; 45 851-3
- 11 Silva M, Cruz M A. Some constituents of Pitavia punctata . Phytochemistry. 1971; 10 3255-8
- 12 Hoult J RS, Payà M. Pharmacological and biochemical actions of simple coumarins: natural products with therapeutic potential. Gen Pharmac. 1996; 27 713-22
- 13 Andriambeloson A, Magnier C, Haan-Archipoff G, Lobstein A, Anton R, Beretz A, Stoclet J C, Andriantsitohaina R. Natural dietary polyphenolic compounds cause endothelium-dependent vasorelaxation in rat thoracic aorta. J Nutr. 1998; 128 2324-33
Ramaoson Andriantsitohaina
UMR/CNRS 7034
Faculté de Pharmacie
Université Louis Pasteur
Strasbourg
France
Email: hain@pharma.u-strasbg.fr
Phone: +33-390244245
Fax: +33-390244313