Das Ende der Supplementierung mit antioxidativen Vitaminen

Zusammenfassung

Der Goldstandard für medikamentöse und diätetische Studien bleibt die randomisierte, plazebokontrollierte Interventionsstudie. Um die Wirksamkeit der antioxidativen Vitamine auf die Verhütung der Atherogenese und Karzinogenese zu prüfen, wurden in den vergangenen zehn Jahren neun randomisierte Interventionsstudien an über 110 000 Männern und Frauen in Europa und den USA durchgeführt. In keiner dieser über mindestens drei und maximal zwölf Jahre laufenden Studien wurden im Vergleich zu Plazebo positive Ergebnisse erreicht. Vom Gebrauch von Supplementen mit hohen Dosen von antioxidativen Vitaminen sollte in Zukunft abgeraten werden, da bereits erste Resultate mit hohen Dosen von Vitaminen auf gefährliche Komplikationen hinweisen.

Abstract

Between 1992 and 2002, the results of nine randomized, placebo-controlled trials were reported after testing the effectiveness of antioxidant vitamins to prevent or treat coronary heart disease and cancer. A total of over 110 000 men and women in the United States and Europe were involved in these double-blind intervention studies for a minimum of three and a maximum of twelve years. Antioxidant vitamins in various supplement dosages were shown ineffective to influence atherogenesis, and, in two studies, the combination of beta-carotene treatment and smoking appeared to increase the incidence of lung cancer. Therefore, the use of vitamin supplements is to be discouraged.

Schlüsselwörter

β-Karotin - Vitamin E - Vitamin C - Supplemente - klinische Wirksamkeit

Key words

β-carotene - vitamin E - vitamin C - supplements - clinical outcome

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