Indium-Mediated Allylation Reaction in Aqueous Media: Synthetic Studies Towards the Total Synthesis of Dysiherbaine [1]

Abstract

A stereospecific route to the key intermediate 4 for the total synthesis of dysiherbaine has been successfully developed based on the indium-mediated allylation reaction in aqueous media. Further manipulation to the advanced intermediate 28 has resulted in the discovery of a series of highly stereoselective processes.

Key words

indium - allylations - natural products - stereoselectivity - amino acids

References

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11

HPLC grade solvent used without distillation.