Indium-Mediated Allenylation and Propargylation of Allenic Alcohols with Prop-2-ynyl Bromides

Abstract

Indium was found to mediate the reaction between aldehydes and 1-bromo-2-butyne to give E-1-substituted-2,5-dimethyl-heptatrien-1-ol compounds in moderate to good yields. The reaction was extended to the regio- and stereoselective allenylation and propargylation of allenic alcohols with different prop-2-ynyl bromides in the presence of indium and indium tribromide under ultrasonic irradiation.

Key words

indium - allenylation - propargylation - allenic alcohols - prop-2-ynyl bromides

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