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Synthesis 2003(5): 0681-0684
DOI: 10.1055/s-2003-38069
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of N-Benzhydrylamides from Nitriles by Ritter Reactions in Formic Acid

Glen C. Gullickson, David E. Lewis*
Department of Chemistry, University of Wisconsin - Eau Claire, Eau Claire WI 54702-4004, USA
Fax: +1(715)8364979; e-Mail: lewisd@uwec.edu;
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Publikationsverlauf

Received 27 November 2002
Publikationsdatum:
21. März 2003 (online)

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Abstract

Benzhydrol reacts with nitriles in refluxing formic acid to produce amides arising from the Ritter reaction. This reaction does not require a strong acid catalyst, and the products are isolated without the need for chromatography. The conditions permit the preparation of acrylamides and methacrylamides without polymerization of the nitrile.

Key Words

Ritter reaction - alcohols - carboxylic acids - nitriles - amides

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Gullickson, G. C.; Lewis, D. E. Aust. J. Chem., 2003, 56, accepted for publication.