Gastrointestinal Malformations in Two Infants Born to Women with Hyperthyroidism Untreated in the First Trimester

Muhieddine Seoud; Anwar Nassar; Ihab Usta; Mohammad Mansour; Ibrahim Salti; Khaled Younes

doi:10.1055/s-2003-38320

American Journal of Perinatology, Table of Contents

Am J Perinatol 2003; 20(2): 059-062
DOI: 10.1055/s-2003-38320

Gastrointestinal Malformations in Two Infants Born to Women with Hyperthyroidism Untreated in the First Trimester

Muhieddine Seoud¹ , Anwar Nassar¹ , Ihab Usta¹ , Mohammad Mansour¹ , Ibrahim Salti² , Khaled Younes³

¹Obstetrics and Gynecology, The American University of Beirut Medical Center, New York, New York
²Internal Medicine, The American University of Beirut Medical Center, New York, New York
³Pediatrics, The American University of Beirut Medical Center, New York, New York

Abstract

ABSTRACT

We report two infants with gastrointestinal anomalies: one with esophageal atresia and tracheo-esophageal fistula and the other with biliary tree atresia, born to hyperthyroid women diagnosed and treated with methimazole after 14 weeks' gestation. Euthyroidism was documented in both infants. These cases raise the issue of whether untreated hyperthyroidism and not methimazole intake is the teratogen.

KEYWORDS

Hyperthyroidism - methimazole - gastrointestinal anomalies

Full Text

References

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