A completely odourless reliable synthesis of styrenic resins
containing 1,3-propanedithiol functions able to form 1,3-dithiane
derivatives with carbonyl compounds and back up the chemistry of
thioacetals and thioketals is reported. The degree of functionalisation
of the resin can be easily determined through the composition of
the copolymerising mixture and confirmed by titration. The resins
show good accessibility to various reagents and are effective for
solid-phase synthesis being exploitable in the field of combinatorial
chemistry.
solid-phase synthesis - polymeric dithiols - polymeric dithianes - umpolung reactions - ketones
