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DOI: 10.1055/s-2003-38775
© Georg Thieme Verlag Stuttgart · New York
Helicobacter pylori Infection Does not Affect the Early Rebleeding Rate in Patients with Peptic Ulcer Bleeding after Successful Endoscopic Hemostasis: A Prospective Single-Center Trial
Publication History
Submitted 29 April 2002
Accepted after Revision 11 November 2002
Publication Date:
17 April 2003 (online)
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Background and Study Aims: Eradication of Helicobacter pylori infection can reduce the rebleeding rate of peptic ulcer bleeding in the long term. There are few data on the influence of H. pylori on the rebleeding rate in the acute phase of bleeding however. We therefore prospectively investigated the influence of H. pylori infection on the early rebleeding rate in patients who had undergone successful endoscopic hemostasis treatment for peptic ulcer bleeding.
Patients and Methods: Between January 1996 and November 2000 all patients with peptic ulcer bleeding were evaluated consecutively. The diagnosis of H. pylori infection was made at index endoscopy, using histology and the rapid urease test. Bleeding activity was assessed using the Forrest classification. After successful endoscopic hemostasis all patients received omeprazole 40 mg or pantoprazole 40 mg, intravenously, twice a day for 3 days. Rebleeding episodes were recorded over 21 days following primary hemostasis.
Results: 344 patients were enrolled into the study. The prevalence of H. pylori infection was 62.9 %. A total of 51 patients showed rebleeding (14.8 %), of whom 31 were H. pylori-positive (60 %). There was no statistically significant difference between the H. pylori-positive and -negative patients, however. The rebleeding rate did not differ between patients with H. pylori infection alone and patients also using nonsteroidal anti-inflammatory drugs. When stratifying patients according to activity of bleeding at index endoscopy, we were also unable to find any significant influence of H. pylori infection on the outcome of Forrest class I and IIa bleedings.
Conclusion: Based on our data, it can be concluded that H. pylori infection does not affect the early rebleeding rate in patients with peptic ulcer bleeding after successful endoscopic hemostasis.
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D. Schilling, M.D.
Department of Internal Medicine C (Gastroenterology and Hepatology) · Klinikum der Stadt Ludwigshafen · Academic Medical Hospital of the University of Mainz
Bremerstrasse 79 · 67063 Ludwigshafen/Rhine · Germany
Fax: + 49-621-503-4114
Email: MedCLu@t-online.de