RSS-Feed abonnieren
DOI: 10.1055/s-2003-38924
6 Laser im oberen Aerodigestivtrakt bei bösartigen Erkrankungen
Publikationsverlauf
Publikationsdatum:
28. April 2003 (online)
![](https://www.thieme-connect.de/media/lro/2003S1/lookinside/thumbnails/10.1055-s-2003-38924-1.jpg)
Zusammenfassung
Die transorale Lasermikrochirurgie entwickelte sich in den letzten Jahren zu einer Operationsmethode, die den minimal-invasiven Zugangsweg mit den besonderen Vorzügen des Lasers - der chirurgischen Präzision, der leichten Steuerbarkeit, der optimierten Gewebewirkung und der berührungslosen Vorgehensweise - in sich vereinigt. Die Prinzipien der lasermikrochirurgischen Resektion von Mundhöhlen-, Oro-, Hypopharynx- und Larynxkarzinomen werden beschrieben und die onkologischen und funktionellen Ergebnisse der Lasermikrochirurgie den Ergebnissen der konkurrierenden Standardtherapieverfahren gegenübergestellt. Die Vorteile der Lasermikrochirurgie in der Behandlung früher Stimmlippenkarzinome sind weithin anerkannt. Der Stellenwert der Laserchirurgie in der Behandlung von Stimmlippenkarzinomen mit Bewegungseinschränkung oder Fixation der Stimmlippe ist noch nicht abschließend zu beurteilen. Nach den bisher vorliegenden Ergebnissen kann in etwa 70 % der Fälle mit der primären Therapie lokale Tumorfreiheit mit funktionsfähigem Restkehlkopf erzielt werden. Beim Larynxkarzinomrezidiv nach primärer Strahlentherapie ist die Lasermikrochirurgie den klassischen Larynxteilresektionen in onkologischer Hinsicht vergleichbar, sie hat jedoch weniger Komplikationen. Beim frühen und beim mäßig weit fortgeschrittenen supraglottischen Karzinom ist die Lasermikrochirurgie der klassischen Kehlkopfteilresektion im Hinblick auf die lokale Kontrolle und das Überleben vergleichbar. Gemessen am Organerhalt ist sie den klassischen Teilresektionen vergleichbar, der primären Strahlentherapie jedoch überlegen. Durch die Mikrochirurgie können funktionell wichtige Strukturen geschont werden, so dass eine frühe Schluckrehabilitation unter Vermeidung der Tracheotomie möglich ist. Auch Karzinome des Hypopharynx können unter Organ- und Funktionserhalt mit guten onkologischen Ergebnissen mit dem Laser operiert werden. Verglichen mit der Standardtherapie und neueren Protokollen mit dem Ziel des Organerhalts (neoadjuvante Chemotherapie und Radiotherapie, simultane Chemo-Radiotherapie) stellt die Lasermikrochirurgie eine therapeutische Alternative dar. Bei Mundhöhlen- und Oropharynxkarzinomen bedeutet der en- oder transorale Zugangsweg durch den Verzicht auf Pharyngotomie, Unterkieferspaltung bzw. Unterkieferteilresektion und Tracheotomie weit weniger Morbidität für den Patienten. Auch große Defekte in Mundhöhle und Oropharynx müssen nicht plastisch verschlossen werden. Der Verzicht auf eine plastische Deckung muss für die postoperative Schluck- und Sprechfunktion nicht nachteilig sein.
Schlüsselwörter
CO2-Lasermikrochirurgie - Plattenepithelkarzinom - Oberer Aerodigestivtrakt - Larynx - Hypopharynx - Oropharynx - Mundhöhle
Literatur
-
1 Braun U.
Anesthesiological aspects of laser surgery in otorhinolaryngology. In: Steiner W, Ambrosch P Endoscopic laser surgery of the upper aerodigestive tract. With special emphasis on cancer surgery. Stuttgart, New York; Georg Thieme Verlag 2000: 116-123 - 2 Shikowitz M J, Abramson A L, Liberatore L. Endolaryngeal jet ventilation: a 10-year review. Laryngoscope. 1991; 101 455-461
- 3 Claes J, Vermeyen K, van der Heyning P H, Boeckx E. Preglottic low-frequency Venturi jet ventilation in laryngoscopic microsurgery in adults. The influence of inspiratory time and frequency of ventilation. Clin Otolaryngol. 1989; 14 433-440
- 4 Steiner W, Ambrosch P. Endoscopic laser surgery of the upper aerodigestive tract. Stuttgart, New York; Georg Thieme 2000
- 5 Ambrosch P, Brinck U, Fischer G, Steiner W. Spezielle Aspekte der histopathologischen Diagnostik bei der Lasermikrochirurgie von Karzinomen des oberen Aerodigestivtraktes. Laryngorhinootologie. 1994; 73 78-83
- 6 Davidson T M, Nahum A M, Haghighi P, Astarita S L, Saltzstein S, Seagren S. The biology of head and neck cancer. Detection and control by parallel histologic sections. Arch Otolaryngol. 1984; 110 193-196
- 7 Davidson T M, Haghighi P. Parallel histologic section for head and neck mucosal cancer. Facial Plast Surg. 1987; 5 67-90
- 8 Kleinsasser O, Glanz H. Histologisch kontrollierte Tumorchirurgie. HNO. 1984; 32 234-236
- 9 Strong M S, Jako J. Laser surgery in the larynx. Early clinical experience with continuous CO2 laser. Ann Otol Rhinol Laryngol. 1972; 81 791-798
- 10 Kleinsasser O, Glanz H, Kimmich T. Endoskopische Chirurgie des Stimmlippenkarzinoms. HNO. 1988; 36 412-416
- 11 Steiner W. Experience in endoscopic laser surgery of malignant tumours of the upper aerodigestive tract. Adv Otorhinolaryngol. 1988; 39 135-144
- 12 Remacle M, Lawson G, Jamart J, Minet M, Watelet J B, Delos M. CO2 laser in the diagnosis and treatment of early cancer of the vocal fold. Eur Arch Otorhinolaryngol. 1997; 254 169-176
- 13 Thumfart W F, Eckel H E. Endolaryngeale Laserchirurgie zur Behandlung von Kehlkopfkarzinomen. HNO. 1990; 38 174-178
- 14 Remacle M, Eckel H E, Antonelli A, Brasnu D, Chevalier D, Friedrich G, Olofsson J, Rudert H H, Thumfart W F, de Vincentiis M, Wustrow T PU. Endoscopic cordectomy. A proposal for a classification by the working committee, European Laryngological Society. Eur Arch Otorhinolaryngol. 2000; 257 227-231
- 15 Shapshay S M, Hybels R L, Bohigian R K. Laser excision of early vocal cord carcinoma: indications, limitations, and precautions. Ann Otol Rhinol Laryngol. 1990; 99 46-50
- 16 Eckel H E, Thumfart W F. Laser surgery for the treatment of larynx carcinomas: indications, techniques, and preliminary results. Ann Otol Rhinol Laryngol. 1992; 101 113-118
- 17 Steiner W. Results of curative laser microsurgery of laryngeal carcinomas. Am J Otolaryngol. 1993; 14 116-121
- 18 Czigner J, Sávay L. Primäre CO2-Laser-Chordektomie beim Stimmlippenkarzinom. Laryngo-Rhino-Otol. 1994; 73 432-436
- 19 Rudert H H, Werner J A. Endoscopic resections of glottic and supraglottic carcinomas with the CO2 laser. Eur Arch Otorhinolaryngol. 1995; 252 146-148
-
20 Lindholm C E, Elner A.
Transoral laser surgery of laryngeal carcinomas. In: Rudert H, Werner JA (Eds) Lasers in otorhinolaryngology and in head and neck surgery. Adv Otorhinolaryngol 49. Basel; Karger 1995: 250-253 - 21 Thumfart W F, Scholtz A W, Eckel H E, Gunkel A R, Pototschnig C. Early cancer of the larynx. Proceedings of the Fourth International Conference on Head and Neck Cancer, Toronto, July 28-August 1. 1996: 289-297
- 22 Motta G, Esposito E, Cassiano B, Motta S. T1-T2-T3 glottic tumors: fifteen years experience with CO2 laser. Acta Otolaryngol (Stockh). 1997; 527 155-159
-
23 Peretti G, Cappiello J, Berlucchi M, Ansarin M, Antonelli A R.
Transoral CO2 laser surgery for Tis, T1 and T2 glottic cancer. In: Kleinsasser O, Glanz H, Olofsson J (Eds) Advances in Laryngology in Europe. Amsterdam, the Netherlands; Elsevier 1997: 270-275 - 24 Mahieu H, Peeters J, Snel F, Leemans R. Transoral endoscopic surgery for early glottic cancer. Proceedings of the Fifth International Conference on Head and Neck Cancer, San Francisco, July 29-August 2. 2000: 165-172
- 25 Ambrosch P, Rödel R, Kron M, Steiner W. Die transorale Lasermikrochirurgie des Larynxkarzinoms. Eine retrospektive Analyse von 657 Patientenverläufen. Onkologe. 2001; 7 505-512
- 26 Peretti G, Nicolai P, Piazza C, Redaelli de Zinis L O, Valentini S, Antonelli A R. Oncological results of endoscopic resections of Tis and T1 glottic carcinomas by carbon dioxide laser. Ann Otol Rhinol Laryngol. 2001; 110 820-826
- 27 Gallo A, de Vincentiis M, Manciocco V, Simonelli M, Fiorella M L, Shah J P. CO2 laser cordectomy for early-stage glottic carcinoma: a long-term follow-up of 156 cases. Laryngoscope. 2002; 112 370-374
- 28 Eckel H E. Local recurrences following transoral laser surgery for early glottic carcinoma: frequency, management, and outcome. Ann Otol Rhinol Laryngol. 2001; 110 7-15
- 29 Glanz H, Kimmich T, Eichhorn T, Kleinsasser O. Ergebnisse der Behandlung von 584 Kehlkopfkarzinomen an der HNO-Klinik Marburg. HNO. 1989; 37 1-10
- 30 Johnson J T, Myers E N, Hao S P, Wagner R L. Outcome of open surgical therapy for glottic carcinoma. Ann Otol Rhinol Laryngol. 1993; 102 752-755
- 31 Neel H B III, Devine K D, DeSanto L W. Laryngofissure and cordectomy for early cordal carcinoma: Outcome in 182 patients. Otolaryngol Head Neck Surg. 1980; 88 79-84
- 32 Thomas J V, Olsen K D, Neel H B 3rd, De Santo L W, Suman V J. Recurrences after endoscopic management of early (T1) glottic carcinoma. Laryngoscope. 1994; 104 1099-1104
- 33 Ton-Van J, Lefebvre J L, Stern J C, Buisset E, Coche-Dequeant B, Vankemmel B. Comparison of surgery and radiotherapy in T1 and T2 glottic carcinomas. Am J Surg. 1991; 162 337-340
- 34 Epstein B E, Lee D J, Kashima H, Johns M E. Stage T1 glottic carcinoma: results of radiation therapy or laser excision. Radiology. 1990; 175 567-570
- 35 Fein D A, Mendenhall W M, Parsons J T, Million R R. T1 - T2 squamous cell carcinoma of the glottic larynx treated with radiotherapy: a multivariate analysis of variables potentially influencing local control. Int J Radiat Oncol Biol Phys. 1993; 25 605-611
- 36 Grant D G, Hussain A, Hurman D. Pre-treatment anaemia alters outcome in early squamous cell carcinoma of the larynx treated by radical radiotherapy. J Laryngol Otol. 1999; 113 829-833
- 37 Jorgensen K, Godballe C, Hansen O, Bastholt L. Cancer of the larynx. Treatment results after primary radiotherapy with salvage surgery in a series of 1005 patients. Acta Oncol. 2002; 41 69-76
- 38 Mendenhall W M, Parsons J T, Stringer S P, Cassissi N J. Management of Tis, T1, and T2 squamous cell carcinoma of the glottic larynx. Am J Otolaryngol. 1994; 15 250-257
- 39 Rosier J F, Grégoire V, Counoy H, Octave Prignot M, Rombaut P, Scalliet P, Vanderlinden F, Hamoir M. Comparison of external radiotherapy, laser microsurgery and partial laryngectomy for the treatment of T1N0M0 glottic carcinomas; a retrospective evaluation. Radiother Oncol. 1998; 48 175-183
- 40 van der Voet J C, Keus R B, Hart A A, Hilgers F J, Bartelink H. The impact of treatment time and smoking on local control and complications in T1 glottic cancer. Int J Radiat Oncol Biol Phys. 1998; 42 247-255
- 41 Barthel S W, Esclamado R M. Primary radiation therapy for early glottic cancer. Otolaryngol Head Neck Surg. 2001; 124 35-39
- 42 Dinshaw K A, Sharma V, Agarwal J P, Ghosh S, Havaldar R. Radiation therapy in T1 - T2 glottic carcinoma: influence of various treatment parameters on local control/complications. Int J Radiat Oncol Biol Phys. 2000; 48 723-735
- 43 Marshak G, Brenner B, Shvero J, Shapira J, Ophir D, Hochman I, Marshak G, Sulkes A, Rakowsky E. Prognostic factors for local control of early glottic cancer: the Rabin medical center retrospective study on 207 patients. Int J Radiat Oncol Biol Phys. 1999; 43 1009-1013
- 44 Schwaab G, Mamelle G, Lartigau E, Parise O, Wibault P, Luboinski B. Surgical salvage treatment of T1/T2 glottic carcinoma after failure of radiotherapy. Am J Surg. 1994; 168 474-475
- 45 Reker U. Phoniatory ability after surgery of vocal cord carcinoma of limited extension. A comparison between transoral laser microsurgery and frontolateral partial laryngeal resection. Adv Otorhinolaryngol. 1995; 49 215-218
- 46 Dagli A S, Mahieu H F, Festen J M. Quantitative analysis of voice quality in early glottic laryngeal carcinomas treated with radiotherapy. Eur Arch Otolaryngol. 1997; 254 78-80
- 47 Verdonck-De Leeuw I M, Keus R B, Hilgers F JM, Koopmans-van Beinum F J, Greven A J, Jongde J MA, Vreeburg G, Bartelink H. Consequences of voice impairment in daily life for patients following radiotherapy for early glottic cancer: voice quality, vocal function, and vocal performance. Int J Rad Oncol Biol Phys. 1999; 44 1071-1078
- 48 Keilmann A, Bergler W, Artzt M, Hörmann K. Vocal function following laser and conventional surgery of small malignant vocal fold tumours. J Laryngol Otol. 1996; 110 1138-1141
- 49 Pia F, Gonella M L, Boggero R, Ponzo S, Giordano C. Valutazione obiettivo-instrumentale della funzionalità glottica residua dopo cordectomia tradizionale e cordectomia CO2 laser. Acta Otorhinolaryngol Ital. 1994; 14 329-338
- 50 Brandenburg J H. Laser cordotomy versus radiotherapy: an objective cost analysis. Ann Otol Rhinol Laryngol. 2001; 110 312-317
- 51 Delsupehe K G, Zink I, Lejaegere M, Bastian R W. Voice quality after narrow-margin laser cordectomy compared with laryngeal irradiation. Otolaryngol Head Neck Surg. 1999; 121 528-533
- 52 McGuirt W F, Blalock D, Koufman J A, Feehs R S, Hilliard A J, Greven K, Randall M. Comparative voice results after laser resection or irradiation of T1 vocal cord carcinoma. Arch Otolaryngol Head Neck Surg. 1994; 120 951-955
- 53 Haraf D J, Weichselbaum R R. Treatment selection in T1 and T2 vocal cord carcinoma. Acta Oncol. 1991; 30 357-362
- 54 Rydell R, Schalén L, Fex S, Elner A. Voice evaluation before and after laser excision vs. radiotherapy of T1A glottic carcinoma. Acta Otolaryngol (Stockh). 1995; 115 560-565
-
55 Kruse E.
The role of the phoniatrician in laser surgery of the larynx. In: Steiner W, Ambrosch P (Eds) Endoscopic laser surgery of the upper aerodigestive tract. With special emphasis on cancer surgery. Stuttgart, New York; Georg Thieme Verlag 2000: 124-129 - 56 Steiner W, Aurbach G, Ambrosch P. Minimally invasive therapy in otorhinolaryngology and head and neck surgery. MITAT. 1991; 108 57-70
- 57 Myers E N, Wagner R L, Johnson J T. Microlaryngoscopic surgery for T1 glottic lesions: a cost-effective option. Ann Otol Rhinol Laryngol. 1994; 103 28-30
- 58 Paulsen F, Tillmann B. Struktur und Funktion des ventralen Stimmlippenansatzes. Unter klinischen Gesichtspunkten. Laryngo-Rhino-Otol. 1996; 75 590-596
- 59 Rucci L, Gammarota L, Borghi Cirri M B. Carcinoma of the anterior commissure of the larynx: I. Embryological and anatomic considerations. Ann Otol Rhinol Laryngol. 1996; 105 303-308
- 60 Rucci L, Gammarota L, Gallo O. Carcinoma of the anterior commissure of the larynx: II. Proposal of a new staging system. Ann Otol Rhinol Laryngol. 1996; 105 391-396
- 61 Kirchner J A, Carter D. Intralaryngeal barriers to the spread of cancer. Acta Otolaryngol (Stockh). 1987; 103 503-513
- 62 Kirchner J A. What have whole organ sections contributed to the treatment of laryngeal cancer?. Ann Otol Rhinol Laryngol. 1989; 98 661-667
- 63 Krespi Y P, Meltzer C J. Laser surgery for vocal cord carcinoma involving the anterior commissure. Ann Otol Rhinol Laryngol. 1989; 98 105-109
- 64 Casiano R, Cooper J D, Lundy D S, Chandler J R. Laser cordectomy for T1 glottic carcinoma: a 10-year experience and videostroboscopic findings. Otolaryngol Head Neck Surg. 1991; 104 831-837
- 65 Wetmore S J, Key M, Suen J Y. Laser therapy for T1 glottic carcinoma of the larynx. Arch Otolaryngol Head Neck Surg. 1986; 112 853-855
- 66 Wolfensberger M, Dort J C. Endoscopic laser surgery for early glottic carcinoma: a clinical and experimental study. Laryngoscope. 1990; 100 1100-1105
- 67 Davis R K, Jako G J, Hyams V J, Shapshay S M. The anatomic limitations of CO2 laser cordectomy. Laryngoscope. 1982; 92 980-984
- 68 Desloge R B, Zeitels S M. Endolaryngeal microsurgery at the anterior glottal commissure: controversies and observations. Ann Otol Rhinol Laryngol. 2000; 109 385-392
- 69 Kashima H K, Lee D-J, Zinreich S J. Vestibulectomy in early vocal fold carcinoma. Trans Am Broncho-Esophagol Assoc. 1991; 71 28-32
-
70 Rudert H H.
Transoral CO2-laser surgery of early glottic cancer (CIS - T2). In: Smee R, Bridger P (Eds) Laryngeal Cancer: Proceedings of the 2nd World Congress on Laryngeal Cancer. Amsterdam, the Netherlands; Elsevier 1994: 389-392 - 71 Steiner W, Ambrosch P, Rödel R MW, Kron M. Carbon dioxide laser microsurgery for early glottic carcinoma: The impact of anterior commissure involvement on local control. 2003: in press
- 72 Hirota S, Soejima T, Obayashi K, Hishikawa Y, Honda K, Okamoto Y, Maeda H, Takada Y, Inoue K, Kinishi M, Amatsu M, Kimura S. Radiotherapy of T1 and T2 glottic cancer: analysis of anterior commissure involvement. Radiat Med. 1996; 14 297-302
- 73 Maheshwar A A, Gaffney C C. Radiotherapy for T1 glottic carcinoma: impact of anterior commissure involvement. J Laryngol Otol. 2001; 115 298-301
- 74 Reddy S P, Mohideen N, Marra S, Marks J E. Effect of tumour bulk on local control and survival of patients with T1. Radiother Oncol. 1998; 47 161-166
- 75 Rudoltz M S, Benammar A, Mohiuddin M. Prognostic factors for local control and survival in T1 squamous cell carcinoma of the glottis. Int J Radiat Oncol Biol Phys. 1993; 26 767-772
- 76 Rucci L, Gallo O, Fini-Storchi O. Glottic cancer involving anterior commissure: surgery vs. radiotherapy. Head Neck. 1991; 13 403-410
- 77 Woodhause R J, Quivey J M, Fu K K, Sein P S, Dedo H H, Phillips T L. Treatment of carcinoma of the vocal cord. A review of 20 years experience. Laryngoscope. 1981; 91 1155-1162
- 78 Zohar Y, Rahima M, Shvili Y, Talmi Y P, Lurie H. The controversial treatment of anterior commissure carcinoma of the larynx. Laryngoscope. 1992; 102 69-72
- 79 Mallet Y, Chevalier D, Darras J A, Wiel E, Desaulty A. Near total laryngectomy with epiglottic reconstruction. Our experience of 65 cases. Eur Arch Otorhinolaryngol. 2001; 258 488-491
- 80 Laccourreye O, Muscatello L, Laccourreye L, Naudo P, Brasnu D, Weinstein G. Supracricoid partial laryngectomy with cricohyoidoepiglottopexy for „early” glottic carcinoma classified as T1 - T2N0 invading the anterior commissure. Am J Otolaryngol. 1997; 18 385-390
- 81 Bron L, Brossard E, Monnier P, Pasche P. Supraglottic partial laryngectomy with cricohyoidoepiglottopexy and cricohyoidopexy for glottic and supraglottic carcinomas. Laryngoscope. 2000; 110 27-634
- 82 Bron L P, Soldati D, Zouhair A, Ozsahin M, Brossard E, Monnier P, Pasche P. Treatment of early stage squamous-cell carcinoma of the glottic larynx: endoscopic surgery or cricohyoidoepiglottopexy versus radiotherapy. Head Neck. 2001; 23 823-829
- 83 Bron L, Pasche P, Brossard E, Monnier P, Schweizer V. Functional analysis after supracricoid partial laryngectomy with cricohyoidoepiglottopexy. Laryngoscope. 2002; 112 1289-1293
-
84 Kleinsasser O, Glanz H.
Optional proposals for testing new telescopic ramifications of TNM. In: Hermanek P, Henson DE, Hutter RVP, Sobin LH (Eds) TNM Supplement 1993. Berlin, Heidelberg, New York; Springer 1993: 112-117 - 85 Laccourreye O, Weinstein G, Brasnu D, Trotoux J, Laccourreye H. Vertical partial laryngectomy: a critical analysis of local recurrence. Ann Otol Rhinol Laryngol. 1991; 100 68-71
- 86 Som M L. Cordal cancer with extension to vocal process. Laryngoscope. 1975; 85 1298-1307
- 87 Biller H F, Lawson W. Partial laryngectomy for vocal cord cancer with marked limitation or fixation of the vocal cord. Laryngoscope. 1986; 96 61-64
- 88 Lesinski S G, Bauer W C, Ogura F H. Hemilaryngectomy for T3 (fixed cord) epidermoid carcinoma of the larynx. Laryngoscope. 1976; 86 1563-1571
- 89 Piquet J J, Desaulty A, Pilliaert J M, Decroix G. Results of surgical treatment of cancers of the endolarynx. Acta Otorhinolaryngol Belg. 1973; 27 916-923
- 90 Vega S F, Scola B, Vega M F, Martinez T, Scola E. Laryngeal vertical partial surgery. Surgical techniques. Oncological and functional results. Acta Otorhinolaryngol Ital. 1996; 16 272-280
- 91 Bryant G P, Poulsen M G, Tripcony L, Dickie G J. Treatment decisions in T3N0M0 glottic carcinoma. Int J Radiat Oncol Biol Phys. 1995; 31 285-293
- 92 Foote R L, Olsen K D, Buskirk S J, Stanley R J, Suman V J. Laryngectomy alone for T3 glottic cancer. Head Neck. 1994; 16 406-412
- 93 Razack M S, Maipang T, Sako K, Bakamjian V, Shedd D P. Management of advanced glottic cancer. Am J Surg. 1989; 159 318-320
- 94 Chevalier D, Laccourreye O, Brasnu D, Laccourreye H, Piquet J J. Cricohyoidoepiglottopexy for glottic carcinoma with fixation or impaired motion of the true vocal cord: 5-year oncologic results with 112 patients. Ann Otol Rhinol Laryngol. 1997; 106 364-369
- 95 Piquet J J, Chevalier D. Subtotal laryngectomy with crico-hyoido-epiglotto-pexy for the treatment of extended glottic carcinoma. Am J Surg. 1991; 162 357-361
- 96 Laccourreye O, Salzer S J, Brasnu D, Shen W, Laccourreye H, Weinstein G S. Glottic carcinoma with a fixed true vocal cord: Outcomes after neoadjuvant chemotherapy and supracricoid partial laryngectomy with cricohyoidoepiglottopexy. Otolaryngol Head Neck Surg. 1996; 114 400-406
- 97 Laccourreye O, Brasnu D, Biacabe B, Hans S, Seckin S, Weinstein G. Neo-adjuvant chemotherapy and supracricoid partial laryngectomy with cricohyoidopexy for advanced endolaryngeal carcinoma classified as T3 - T4 : 5-year oncologic results. Head Neck. 1998; 20 595-599
- 98 Laccourreye O, Diaz E M, Muscatello L, Garcia D, Brasnu D. A multimodal strategy for the treatment of patients with T2 invasive squamous cell carcinoma of the glottis. Cancer. 1999; 85 40-46
- 99 Laccourreye O, Laccourreye L, Muscatello L, Périé S, Weinstein G, Brasnu D. Local failure after supracricoid partial laryngectomy: symptoms, management, and outcome. Laryngoscope. 1998; 108 339-344
- 100 Burke L S, Greven K M, McGuirt W T, Case D, Hoen H M, Raben M. Definitive radiotherapy for early glottic carcinoma: prognostic factors and implications for treatment. Int J Radiat Oncol Biol Phys. 1997; 38 1001-1006
- 101 Mendenhall W M, Parsons J T, Stringer S P, Cassisi N J, Million R R. T1 - T2 vocal cord carcinoma: a basis for comparing the results of radiotherapy and surgery. Head Neck Surg. 1988; 10 373-377
- 102 Turesson I, Sandberg N, Mercke C, Johansson K A, Sandin I, Wallgren A. Primary radiotherapy for glottic laryngeal carcinoma stage I and II. A retrospective study with special regard to failure patterns. Acta Oncol. 1991; 30 357-362
- 103 Harwood A R, Bryce D P, Rider W D. Management of T3 glottic cancer. Arch Otolaryngol. 1980; 106 697-699
- 104 Mendenhall W M, Parsons J T, Mancuso A A, Pameijer F J, Stringer S P, Cassissi N J. Definitive radiotherapy for T3 squamous cell carcinoma of the glottic larynx. J Clin Oncol. 1997; 15 2394-2402
- 105 Parsons J T, Mendenhall W M, Mancuso A A, Cassisi N J, Stringer S P, Million R R. Twice-a-day radiotherapy for T3 squamous cell carcinoma of the glottic larynx. Head Neck. 1989; 11 123-128
- 106 Wylie J P, Sen M, Swindell R, Sykes A J, Farrington W T, Slevin N J. Definitive radiotherapy for 114 cases of T3N0 glottic carcinoma: influence of dose-volume parameters on outcome. Radiotherapy and Oncology. 1999; 53 15-21
- 107 Department of Veterans Affairs Laryngeal Cancer Study Group . Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. N Engl J Med. 1991; 324 1685-1690
- 108 Wolf G T, Hong W K, Fisher S G. Neoadjuvant chemotherapy for organ preservation: current status. Proceedings 4th International Conference on Head and Neck Cancer. 1996; 4 89-97
- 109 Richard J M, Sancho-Garnier H, Pessey J J, Luboinski B, Lefebvre J L, Dehesdin D, Stromboni-Luboinski M, Hill C. Randomized trial of induction chemotherapy in larynx carcinoma. Oral Oncol. 1998; 34 224-228
- 110 Janot F, Rhein B, Koka V N, Wibault P, Domenge C, Bessede J P, Marandas P, Schwaab G, Luboinski B. Laryngeal preservation with induction chemotherapy. Experience of two GETTEC Centers, between 1985 and 1995. Ann Otolaryngol Chir Cervicofac. 2002; 119 12-20
- 111 Viani L, Stell P M, Dalby J E. Recurrence after radiotherapy for glottic carcinoma. Cancer. 1991; 67 577-584
- 112 Kooper D P, van den Broek P, Manni J J, Tiwari R M, Snow G B. Partial vertical laryngectomy for recurrent glottic carcinoma. Clin Otolaryngol. 1995; 20 167-170
- 113 Nibu K, Kamata S, Kawabata K, Nakamizo M, Nigauri T, Hoki K. Partial laryngectomy in the treatment of radiation-failure of early glottic carcinoma. Head Neck. 1997; 19 116-120
- 114 Rodriguez-Cuevas S, Labastida S, Gonzalez D, Briseno N, Cortes H. Partial laryngectomy as salvage surgery for radiation failure in T1-T2 laryngeal cancer. Head Neck. 1998; 20 630-633
- 115 Steiner W, Ambrosch P, Uhlig P, Kron M. CO2 laser microsurgery for hypopharyngeal carcinoma. Proceedings of the 3rd European Congress of the European Federation of Oto-Rhino-Laryngological Societies „EUFOS”, Budapest, 9-14 June 1996. Bologna; Monduzzi Editore S.p. a. 1996: 669-672
- 116 Watters G WR, Patel S G, Rhys-Evans P H. Partial laryngectomy for recurrent laryngeal carcinoma. Clin Otolaryngol. 2000; 25 146-152
- 117 Laccourreye O, Weinstein G, Naudo P, Brasnu D, Cauchois R, Laccourreye H. Supracricoid partial laryngectomy after failed laryngeal radiation therapy. Laryngoscope. 1996; 106 495-498
- 118 Spriano G, Pellini R, Romano G, Muscatello L, Roselli R. Supracricoid partial laryngectomy as salvage surgery after radiation failure. Head Neck. 2002; 24 759-765
- 119 Annyas A A, Overbeek J JM, Escajadillo J R, Hoeksema P E. CO2 laser in malignant lesions of the larynx. Laryngoscope. 1984; 94 836-838
- 120 Blakeslee D, Vaughan C W, Shapshay S M, Simpson G T, Strong M S. Excisional biopsy in the selective management of T1 glottic cancer: A three-year follow-up study. Laryngoscope. 1984; 94 488-494
- 121 De Gier H HW, Knegt P PM, de Boer M F, Meeuwis C A, van der Velden L, Kerrebijn J DF. CO2 laser treatment of recurrent glottic carcinoma. Head Neck. 2001; 23 177-180
- 122 Outzen K E, Illum P. CO2 laser therapy for carcinoma of the larynx. J Laryngol Otol. 1995; 109 111-113
- 123 Quer M, Leon X, Orus C, Venegas P, Lopez M, Burgues J. Endoscopic laser surgery in the treatment of radiation failure of early laryngeal carcinoma. Head Neck. 2000; 8 520-523
- 124 Steiner W, Ambrosch P, Vogt P. Transoral carbon dioxide laser microsurgery for recurrent glottic carcinoma after radiotherapy. 2003: in press
- 125 Alonso J M. Conservative surgery of cancer of the larynx. Trans Am Acad Ophthalmol Otolaryngol. 1947; 51 633-645
- 126 Vaughan C W. Transoral laryngeal surgery using the CO2 laser. Laboratory experiments and clinical experience. Laryngoscope. 1978; 88 1399-1420
- 127 Steiner W, Jaumann M P, Pesch H J. Endoskopische Therapie von Krebsfrühstadien im Larynx - vorläufige Ergebnisse. Arch Otorhinolaryngol. 1981; 231 637-643
- 128 Davis R K, Shapshay S M, Strong M S, Hyams V J. Transoral partial supraglottic resection using the CO2 laser. Laryngoscope. 1983; 93 429-432
- 129 Davis R K, Kelly S M, Hayes J. Endoscopic CO2 laser excisional biopsy of early supraglottic cancer. Laryngoscope. 1991; 101 680-683
- 130 Zeitels S M, Vaughan C W, Domanowski G F. Endoscopic management of early supraglottic cancer. Ann Otol Rhinol Laryngol. 1990; 99 951-956
- 131 Zeitels S M, Koufman J A, Davis R K, Vaughan C W. Endoscopic treatment of supraglottic and hypopharynx cancer. Laryngoscope. 1994; 104 71-78
- 132 Eckel H E. Endoscopic laser resection of supraglottic carcinoma. Otolaryngol Head Neck Surg. 1997; 117 681-687
- 133 Iro H, Waldfahrer F, Altendorf-Hofmann A, Weidenbecher M, Sauer R, Steiner W. Transoral laser surgery of supraglottic cancer. Arch Otolaryngol Head Neck Surg. 1998; 124 1245-1250
- 134 Rudert H H, Werner J A, Höft S. Transoral carbon dioxide laser resection of supraglottic carcinoma. Ann Otol Rhinol Laryngol. 1999; 108 819-827
- 135 Ambrosch P, Kron M, Steiner W. Carbon dioxide laser microsurgery for early supraglottic carcinoma. Ann Otol Rhinol Laryngol. 1998; 107 680-688
- 136 Bocca E, Pignataro O, Oldini C. Supraglottic laryngectomy: 30 years of experience. Ann Otol Rhinol Laryngol. 1983; 92 14-18
- 137 Bocca E. Surgical management of supraglottic cancer and its lymph node metastases in a conservative perspective. Ann Otol Rhinol Laryngol. 1991; 100 261-267
- 138 DeSanto L W. Early supraglottic cancer. Ann Otol Rhinol Laryngol. 1990; 99 593-597
- 139 Herranz-Gonzales J, Gavilan J, Martinez-Vidal J, Gavilan C. Supraglottic laryngectomy: functional and oncologic results. Ann Otol Rhinol Laryngol. 1996; 105 18-22
- 140 Lutz C K, Johnson J T, Wagner R L, Myers E N. Supraglottic carcinoma: patterns of recurrence. Ann Otol Rhinol Laryngol. 1990; 99 12-17
- 141 Robbins K T, Davidson W, Peters L J, Goepfert H. Conservation surgery for T2 and T3 carcinomas of the supraglottic larynx. Arch Otolaryngol Head Neck Surg. 1988; 114 421-426
- 142 Soo K C, Shah J P, Gopinath K S, Gerold F P, Jaques D P, Strong E W. Analysis of prognostic variables and results after supraglottic partial laryngectomy. Am J Surg. 1988; 156 301-305
- 143 Suarez C, Rodrigo J P, Herranz J, Llorente J L, Martinez J A. Supraglottic laryngectomy with or without postoperative radiotherapy in supraglottic carcinomas. Ann Otol Rhinol Laryngol. 1995; 104 358-363
- 144 Martinez T, Escamilla Y, Gutierrez M, Bodoque M, Scola B, Vega M F. La cirugia parcial en el carcinoma supraglotico. Resultados oncologicos y functionales. Acta Otorrinolaring Esp. 1996; 48 125-128
- 145 Maurizi M, Paludetti G, Galli J, Ottaviani F, D'Abramo G, Almadori G. Oncological and functional outcome of conservative surgery for primary supraglottic cancer. Eur Arch Otorhinolaryngol. 1999; 256 283-290
- 146 Myers E N, Alvi A. Management of carcinoma of the supraglottic larynx: evolution, current concepts, and future trends. Laryngoscope. 1996; 106 559-567
- 147 Fletcher G H, Jesse R H, Lindberg R D, Koons C R. The place of radiotherapy in the management of the squamous cell carcinoma of the supraglottic larynx. Am J Roentgenol. 1970; 108 19-26
- 148 Harwood A R, Beale F A, Cummings B J, Keane T J, Payne D G, Rider W D. Management of early supraglottic laryngeal carcinoma by irradiation with surgery in reserve. Arch Otolaryngol. 1983; 109 583-585
- 149 Inoue T A, Matayoshi Y, Inoue T O, Ikeda H, Teshima T, Murayama S. Prognostic factors in telecobalt therapy for early supraglottic carcinoma. Cancer. 1993; 72 57-61
- 150 Mendenhall W M, Parsons J T, Stringer S P, Cassisi N J, Million R R. Carcinoma of the supraglottic larynx: a basis for comparing the results of radiotherapy and surgery. Head Neck. 1990; 12 204-209
- 151 Mendenhall W M, Parsons J T, Mancuso A A, Stringer S P, Cassisi N J. Radiotherapy for squamous cell carcinoma of the supraglottic larynx: an alternative to surgery. Head Neck. 1996; 18 24-35
- 152 Shimm D S, Coulthard S W. Radiation therapy for squamous cell carcinoma of the supraglottic larynx. Am J Clin Oncol. 1989; 12 17-23
- 153 Spaulding C S, Krochak R J, Hahn S S, Constable W C. Radiotherapeutic management of cancer of the supraglottis. Cancer. 1986; 57 1292-1298
- 154 Borgaert W VD, Ostyn F, Schueren E VD. The different clinical presentation, behavior and prognosis of carcinomas originating in the epilarynx and the lower supraglottis. Radiother Oncol. 1983; 1 117-131
- 155 Mancuso A A, Mukherji S K, Schmalfuss I, Mendenhall W, Parsons J, Pameijer F, Hermans R, Kubilis P. Preradiotherapy computed tomography as a predictor of local control in supraglottic carcinoma. J Clin Oncol. 1999; 17 631-637
- 156 Johansen L V, Overgaard J, Hjelm-Hansen M, Gadeberg C. Primary radiotherapy of T1 squamous cell carcinoma of the larynx: analysis of 478 patients treated from 1963 to 1985. Int J Radiat Oncol Biol Phys. 1990; 18 1307-1313
- 157 Hinerman R W, Mendenhall W M, Amdur R J, Stringer S P, Villaret D B, Robbins K T. Carcinoma of the supraglottic larynx: treatment results with radiotherapy alone or with planned neck dissection. Head Neck. 2002; 24 456-467
- 158 Nakfoor B M, Spiro I J, Wang C C, Martins P, Montgomery W, Fabian R. Results of accelerated radiotherapy for supraglottic carcinoma: a Massachusetts General Hospital and Massachusetts Eye and Ear Infirmary experience. Head Neck. 1998; 20 379-384
- 159 Sykes A J, Slevin N J, Gupta N K, Brewster A E. 331 cases of clinically node-negative supraglottic carcinoma of the larynx: a study of a modest size fixed field radiotherapy approach. Int J Radiat Oncol Biol Phys. 2000; 46 1109-1115
- 160 Isaacs J H, Slattery III W H, Mendenhall W M, Cassisi N J. Supraglottic laryngectomy. Am J Otolaryngol. 1998; 19 118-123
- 161 Burstein F D, Calcaterra T C. Supraglottic laryngectomy: Series report and analysis of results. Laryngoscope. 1985; 95 833-836
- 162 Schwaab G, Kolb F, Julieron M, Janot F, Le Ridant A M, Mamelle G, Marandas P, Koka V N, Luboinski B. Subtotal laryngectomy with cricohyoidopexy as first treatment procedure for supraglottic carcinoma: Institut Gustave-Roussy experience (146 cases, 1974 - 1997). Eur Arch Otorhinolaryngol. 2001; 258 246-249
- 163 Chevalier D, Piquet J J. Subtotal laryngectomy with cricohyoidopexy for supraglottic carcinoma: review of 61 cases. Am J Surg. 1994; 168 472-473
- 164 De Vincentiis M, Minni A, Gallo A, Di Nardo A. Supracricoid partial laryngectomies: oncologic and functional results. Head Neck. 1998; 20 504-509
- 165 Laccourreye O, Brasnu D, Merite-Drancy A, Cauchois R, Chabardes E, Menard M, Laccoureye H. Cricohyoidopexy in selected infrahyoid epiglottic carcinomas presenting with pathological preepiglottic space invasion. Arch Otolaryngol Head Neck Surg. 1993; 119 881-886
- 166 Kremer B, Schlöndorff G. Late lethal secondary hemorrhage after laser supraglottic laryngectomy. Arch Otolaryngol Head Neck Surg. 2001; 127 203-205
- 167 Ambrosch P, Steiner W. Komplikationen nach transoraler Lasermikrochirurgie von Mundhöhlen-, Rachen- und Kehlkopfkarzinomen. Otorhinolaryngologia Nova. 1995; 5 268-274
-
168 Serafini I.
Results of supraglottic horizontal laryngectomy. In: Wigand ME, Steiner W, Stell PM (Eds) Functional Partial Laryngectomy. Berlin, Heidelberg, New York; Springer 1984: 223-225 -
169 Vega M F.
Early and late complications after partial resections of the larynx. In: Wigand ME, Steiner W, Stell PM (Eds) Functional Partial Laryngectomy. Berlin, Heidelberg, New York; Springer 1984: 295-298 - 170 Naudo P, Laccourreye O, Weinstein G, Hans S, Lyccourreye H, Brasnu D. Functional outcome and prognostic factors after supracricoid partial laryngectomy with cricohyoidopexie. Ann Otol Rhinol Laryngol. 1997; 106 291-296
- 171 Steininger J R, Parnes S M, Gardner G M. Morbidity of combined therapy for the treatment of supraglottic carcinoma: supraglottic laryngectomy and radiotherapy. Ann Otol Rhinol Laryngol. 1997; 106 151-158
- 172 Spriano G, Antognoni P, Sanguineti G, Sormani M, Richetti A, Ameli F, Piantanida R, Luraghi R, Magli A, Corvo R, Tordiglione M, Vitale V. Laryngeal long-term morbidity after supraglottic laryngectomy and postoperative radiation therapy. Am J Otolaryngol. 2000; 21 14-21
- 173 Suarez C, Rodrigo J P, Herranz J, Diaz C, Fernandez J A. Complications of supraglottic laryngectomy for carcinomas of the supraglottis and the base of the tongue. Clin Otolaryngol. 1996; 21 87-90
- 174 Laccourreye O, Hans S, Borzog-Grayeli A, Maulard-Durdux C, Brasnu D, Housset M. Complications of postoperative radiation therapy after partial laryngectomy in supraglottic cancer: a long-term evaluation. Otolaryngol Head Neck Surg. 2000; 122 752-757
- 175 Flores T C, Wood B G, Koegel L, Levine H L, Tucker H M. Factors in successful deglutition following supraglottic laryngeal surgery. Ann Otol Rhinol Laryngol. 1982; 91 579-583
- 176 Lee N K, Goepfert H, Wendt C D. Supraglottic laryngectomy for intermediate stage cancer: U.T.M.D. Anderson Cancer Center experience with combined therapy. Laryngoscope. 1990; 100 831-836
- 177 Beckhardt R N, Murray J G, Ford C N, Grossman J E, Brandenburg J H. Factors influencing outcome in supraglottic laryngectomy. Head Neck. 1994; 16 232-239
- 178 Hirano M, Tateishi M, Kurita S, Matsuoka H. Deglutition following supraglottic horizontal laryngectomy. Ann Otol Rhinol Laryngol. 1987; 96 7-11
- 179 Logemann J A, Gibbons P, Rademaker A W, Poulski B R, Kahrilas P J, Bacon M, Bowman J, McCracken E. Mechanisms of recovery of swallow after supraglottic laryngectomy. J Speech Hear Res. 1994; 37 965-974
- 180 Rademaker A W, Logemann J A, Pauloski B R, Bowman J B, Lazarus C L, Sisson G A, Milianti F J, Graner D, Cook B S, Collin S L. Recovery of postoperative swallowing in patients undergoing partial laryngectomy. Head Neck. 1993; 15 325-334
- 181 Schweinfurth J M, Silver S M. Patterns of swallowing after supraglottic laryngectomy. Laryngoscope. 2000; 110 1266-1270
- 182 Steiner W, Ambrosch P, Hess C F, Kron M. Organ preservation by transoral laser microsurgery in piriform sinus carcinoma. Otolaryngol Head Neck Surg. 2001; 124 58-67
- 183 Allal A S. Cancer of the pyriform sinus: the trend towards conservative treatment. Bull Cancer. 1997; 84 757-762
- 184 Steiner W. Therapie des Hypopharynxkarzinoms. HNO. 1994; 42 4-13
- 185 Hoffman H T, Karnell L H, Shah J P, Ariyan S, Brown S, Fee W E, Glass A G, Goepfert H, Ossoff R H, Fremgen A M. Hypopharyngeal cancer patient care evaluation. Laryngoscope. 1997; 107 1005-1017
- 186 Hoffman H T, Karnell L H, Funk G F, Robinson R A, Menck H R. The national cancer data base report on cancer of the head and neck. Arch Otolaryngol Head Neck Surg. 1998; 124 951-962
- 187 Carpenter R J, DeSanto L W, Devine K D, Taylor W F. Cancer of the hypopharynx: analysis of treatment and results in 162 patients. Arch Otolaryngol. 1976; 102 716-721
-
188 Steiner W, Herbst M.
Combined therapy of hypopharyngeal carcinoma consisting of endoscopic laser surgery and postoperative radiotherapy. In: Sauer R, Schwab W (Eds) Combined therapy of oropharyngeal and hypopharyngeal carcinoma. München, Wien, Baltimore; Urban & Schwarzenberg 1987: 108-113 -
189 Steiner W.
Therapy of hypopharyngeal carcinoma. In: Johnson JT, Didolkar MS (Eds) Head and Neck Cancer, Vol III. Proceedings of the Third International Conference on Head and Neck Cancer, San Francisco, 26-30 July 1992. Amsterdam, London, New York, Tokyo; Excerpta Medica 1993: 101-109 -
190 Steiner W, Ambrosch P.
CO2 laser microsurgery for hypopharyngeal carcinoma. In: Smee R, Bridger GP (Eds) Laryngeal Cancer. Proceedings of the 2nd World Congress on Laryngeal Cancer, Sydney, 20-24 February 1994. Amsterdam, Lausanne, New York, Oxford, Shannon, Tokyo; Elsevier 1994: 606-609 -
191 Rudert H H.
Laser surgery in the management of carcinoma of the supraglottic larynx and hypopharynx. In: Myers EN, Bluestone CD, Brackmann DE, Krause CJ (Eds) Advances in Otolaryngology, vol. 12. St. Louis; Mosby 1998: 61-80 - 192 Rudert H H. The CO2 laser in the management of hypopharyngeal cancer. Curr Opin Otolaryngol Head Neck Surg. 2002; 10 118-122
- 193 Czaja J M, Gluckman J L. Surgical management of early-stage hypopharyngeal carcinoma. Ann Otol Rhinol Laryngol. 1997; 106 909-913
- 194 Ogura J H, Jurema D A, Watson R K. Partial laryngopharyngectomy and neck dissection for pyriform sinus cancer. Laryngoscope. 1960; 70 1399-1417
- 195 Dumich P S, Pearson B W, Weiland L H. Suitability of near-total laryngo-pharyngectomy in piriform carcinoma. Arch Otolaryngol. 1984; 110 664-669
- 196 Glanz H. Pathomorphologische Aspekte zur transoralen Resektion von Hypopharynxkarzinomen mit Erhalt des Kehlkopfes. Laryngo-Rhino-Otol. 1999; 78 654-662
- 197 Zbären P, Egger C. Growth pattern of piriform sinus carcinomas. Laryngoscope. 1997; 107 511-518
- 198 Ogura J H, Marks J E, Freemann R B. Results of conservation surgery for cancers of the supraglottis and pyriform sinus. Laryngoscope. 1980; 90 591-600
- 199 Laccourreye H, Lacau St Guily J, Brasnu D, Fabre A, Menard M. Supracricoid hemilaryngopharyngectomy. Analysis of 240 cases. Ann Otol Rhinol Laryngol. 1987; 96 217-221
- 200 Spector J G, Sessions D G, Emami B, Simpson J, Haughey B, Harvey J, Frederickson J M. Squamous cell carcinoma of the pyriform sinus: a nonrandomized comparison of therapeutic modalities and long-term results. Laryngoscope. 1995; 105 397-406
- 201 Chevalier D, Watelet J B, Darras J A, Piquet J J. Supraglottic hemilaryngopharyngectomy plus radiation for the treatment of early lateral margin and pyriform sinus carcinoma. Head Neck. 1997; 19 1-5
- 202 Kraus D H, Zelefsky M J, Brock H AJ, Huo J, Harrison L B, Shah J P. Combined surgery and radiation therapy for squamous cell carcinoma of the hypopharynx. Otolaryngol Head Neck Surg. 1997; 116 637-641
- 203 Laccourreye O, Merite-Drancy A, Brasnu D, Chabardes E, Cauchois R, Menard M, Laccourreye H. Supracricoid hemilaryngectomy in selected pyriform sinus carcinoma staged as T2. Laryngoscope. 1993; 103 1379
- 204 Bataini J P, Jaulerry C, Brunin F, Ponvert D, Ghossein N A. Significance and therapeutic implications of tumor regression following radiotherapy in patients treated for squamous cell carcinoma of the oropharynx and pharyngolarynx. Head Neck. 1990; 12 41-49
-
205 Jones A S.
Tumours of the hypopharynx. In: Jones AS, Philipps DE, Hilgers FJ (Eds) Diseases of the Head and Neck, Nose and Throat. New York; Oxford University Press, Inc 1998: 230-249 - 206 Million R R, Cassisi N J. Radical irradiation for carcinoma of the pyriform sinus. Laryngoscope. 1981; 91 439-450
- 207 National Cancer Institut .PDQ® treatment health professionals. July 1999.
- 208 Pameijer F A, Mancuso A A, Mendenhall W M, Parsons J T, Mukherji S K, Hermans R, Kubilis P S. Evaluation of pretreatment computed tomography as a predictor of local control in T1/T2 pyriform sinus carcinoma treated with definitive radiotherapy. Head Neck. 1998; 20 159-169
- 209 Amdur R J, Mendenhall W M, Stringer S P, Villaret D B, Cassisi N J. Organ preservation with radiotherapy for T1- T2 carcinoma of the pyriform sinus. Head Neck. 2001; 23 353-362
- 210 Garden A S, Morrison W H, Clayman G L, Ang K K, Peters L J. Early squamous cell carcinoma of the hypopharynx: outcomes of treatment with radiation alone to the primary disease. Head Neck. 1996; 18 317-322
-
211 Wang C C.
Carcinoma of the hypopharynx. In: Wang CC (Ed) Radiation Therapy for Head and Neck Neoplasms. New York, Chichester, Brisbane, Toronto, Singapore, Weinheim; John Wiley & Sons, Inc 1998: 205-220 - 212 Mendenhall W M, Parsons J T, Stringer S P, Cassisi N J, Million R R. Radiotherapy alone or combined with neck dissection for T1- T2 carcinoma of the pyriform sinus: an alternative to conservation surgery. Int J Radiat Oncol Biol Phys. 1993; 27 1017-1027
- 213 Rodriguez J, Point D, Brunin F, Jaulerry C, Brugere J. Surgery of the hypopharynx after radiotherapy. Bull Cancer Radiother. 1996; 83 17-23
- 214 Davidson J, Keane T, Brown D, Freeman J, Gullane P, Irish J, Rotstein L, Pintilie M, Cummings B. Surgical salvage after radiotherapy for advanced laryngopharyngeal carcinoma. Arch Otolaryngol Head Neck Surg. 1997; 123 420-424
- 215 Wahlberg P CG, Andersson K EH, Biörklund A T, Moller T R. Carcinoma of the hypopharynx: analysis of incidence and survival in Sweden over a 30-year period. Head Neck. 1998; 20 714-719
- 216 Khan A, Spiro J D, Dowsett R, Greenberg B R. Sequential chemotherapy and radiotherapy for organ preservation in advanced resectable nonlaryngeal head and neck cancer. Am J Clin Oncol. 1999; 22 403-407
- 217 Pignon J P, Bourhis J, Domenge C, Designé L. Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. Lancet. 2000; 355 949-955
- 218 Prades J M, Schmitt T M, Timoshenko A P, Simon P G, deCornulier J, Durand M, Guillot A, Martin C. Concomitant chemoradiotherapy in pyriform sinus carcinoma. Arch Otolaryngol Head Neck Surg. 2002; 128 384-388
- 219 Taylor S G, Murthy A K, Griem , Recine D C, Kiel K, Belndowski C, Hurst P B, Showel J T, Hutchinson J C, Campanella R S, Chen S, Caldarelli D D. Concomitant cisplatin/5-FU infusion and radiotherapy in advanced head and neck cancer. 8-year analysis of results. Head Neck. 1997; 19 684-691
- 220 Samant S, Kumar P, Wan J, Hanchett C, Vieira F, Murry T, Wong F S, Robbins K T. Concomitant radiation therapy and targeted cisplatin chemotherapy for the treatment of advanced pyriform sinus carcinoma: disease control and preservation of organ function. Head Neck. 1999; 21 595-601
- 221 Kotz T, Abraham S, Beitler J, Wadler S, Smith R V. Pharyngeal transport dysfunction consequent to an organ-sparing protocol. Arch Otolaryngol Head Neck Surg. 1999; 125 410-413
- 222 Lazarus C, Logemann J A, Pauloski B R, Colangelo L A, Kahrilas P J, Mittal B B, Pierce M. Swallowing disorders in head and neck cancer patients treated with radiotherapy and adjuvant chemotherapy. Laryngoscope. 1996; 106 1157-1166
- 223 Lazarus C, Logemann J A, Shi G, Kahrilas P, Pelzer H, Kleinjan K. Does laryngectomy improve swallowing after chemoradiotherapy? A case study. Arch Otolaryngol Head Neck Surg. 2002; 128 54-57
- 224 Harari P M. Why has induction chemotherapy for advanced head and neck cancer become a united states community standard of practice?. J Clin Oncol. 1997; 15 2050-2055
- 225 Lewin F, Damber L, Jonsson H, Andersson T, Berthelsen A, Biorklund A, Blomqvist E, Evensen J F, Hansen H S, Hansen O, Jetlund O, Mercke C, Modig H, Overgaard M, Rosengren B, Tausjo J, Ringsborg U. Neoadjuvant chemotherapy with cisplatin and 5-fluorouracil in advanced squamous cell carcinoma of the head and neck: a randomized phase III study. Radiother Oncol. 1997; 43 23-28
- 226 Lefebvre J L, Chevalier D, Luboinski B, Kirkpatrick A, Collette L, Sahmoud T. Larynx preservation in pyriform sinus cancer: preliminary results of a European Organization for Research and Treatment of Cancer Phase III Trial. J Natl Cancer Inst. 1996; 88 890-899
- 227 Urba S G, Wolf G T, Bradford C R, Thornton A F, Eisbruch A, Terrell J E, Carpenter V, Miller T, Tang G, Strawderman M. Neoadjuvant therapy for organ preservation in head and neck cancer. Laryngoscope. 2000; 110 2074-2080
- 228 Strong M S, Vaughan C W, Healy G B, Shapshay S M, Jako G J. Transoral management of localized carcinoma of the oral cavity using the CO2 laser. Laryngoscope. 1979; 89 897-905
- 229 Chiesa F, Tradati N, Sala L, Costa L, Podrecca S, Boracchi P, Bandieramonte G, Mauri M, Molinari R. Follow-up of oral leukoplakia after carbon dioxide laser surgery. Arch Otolaryngol Head Neck Surg. 1990; 116 177-180
- 230 Chu F WK, Silverman S, Dedo H H. CO2 laser treatment of oral leukoplakia. Laryngoscope. 1988; 98 125
- 231 Frame J W, Morgan D, Rhys Evans P H. Tongue resection with the CO2 laser: the effect of past radiotherapy on postoperative complications. Br J Oral Maxillofac Surg. 1988; 26 464-471
-
232 Davis R K.
Laser surgery for oral cavity and oropharyngeal cancer. In: Davis RK (Ed) Lasers in otolaryngology - head and neck surgery. Philadelphia; Saunders 1990 - 233 Guerry T L, Silverman S Jr, Dedo H H. Carbon dioxide laser resection of superficial oral carcinoma: indications, techniques, and results. Ann Otol Rhinol Laryngol. 1986; 95 547-555
- 234 Nagorsky M J, Sessions D G. Laser resection for early oral cavity cancer. Results and complications. Ann Otol Rhinol Laryngol. 1987; 96 556-560
- 235 Wang C P, Chang S Y, Wu J D, Tai S K. Carbon dioxide laser microsurgery for tongue cancer: surgical techniques and long-term results. J Otolaryngol. 2001; 30 19-23
- 236 Ben-Bassat M, Kaplan I, Shindel Y, Edlan A. The CO2 laser in surgery of the tongue. Br J Plast Surg. 1978; 31 155-156
- 237 Carruth J A. Resection of the tongue with the carbon dioxide laser: 100 cases. J Laryngol Otol. 1985; 99 887-889
- 238 Hirano M, Ohkubo H, Kurita S, Maeda T, Kamimura M, Kawaguchi T, Watanabe Y. CO2 laser in treating carcinoma of the tongue. Auris Nasus Larynx. 1985; 12 10-14
- 239 Williams S R, Carruth J A. The role of the carbon dioxide laser in treatment of carcinoma of the tongue. J Laryngol Otol. 1988; 102 1122-1123
- 240 Eckel H E, Volling P, Pototschnig C, Zorowka P, Thumfart W. Transoral laser resection with staged discontinuous neck dissection for oral cavity and oropharynx squamous cell carcinoma. Laryngoscope. 1995; 105 53-60
- 241 Bier-Laning C, Adams G L. Patterns of recurrence after carbon dioxide laser excision of intraoral squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 1995; 121 1239-1244
-
242 Alvi A, Myers E N, Johnson J T.
Cancer of the oral cavity. In: Myers EN, Suen JY (Eds) Cancer of the Head and Neck. 3rd edition. Philadelphia; Mosby 1996: 321-360 - 243 O'Brien C J, Lahr C J, Soong S. Surgical treatment of early stage carcinoma of the oral tongue. Head Neck Surg. 1986; 8 401-408
- 244 Sessions D G, Spector G J, Lenox J, Haughey B, Chao C, Marks J. Analysis of treatment results for oral tongue cancer. Laryngoscope. 2002; 112 616-625
- 245 Spiro R H, Spiro J D, Strong E W. Surgical approach to squamous cell carcinoma cinfined to the tongue and the floor of the mouth. Head Neck Surg. 1986; 9 27-31
-
246 Shah J P, Lydiatt W M.
Buccal mucosa, alveolus, retromolar trigone, floor of the mouth, hard palate, and tongue tumors. In: Thawley S, Panje WR, Batsakis J, Lindberg RD (Eds) Comprehensive Management of Head and Neck Tumors. 2nd edition. Philadelphia; Saunders 1999: 686-694 - 247 McConnel F M, Teichgraeber J F, Adler R K. A comparison of three methods of oral reconstruction. Arch Otolaryngol Head Neck Surg. 1987; 113 496-500
- 248 McConnel F MS, Pauloski B R, Logemann J A, Rademaker A W, Colangelo L, Shedd D, Carroll W, Lewin J, Johnson J. Functional results of primary closure vs flaps in oropharyngeal reconstruction. Arch Otolaryngol Head Neck Surg. 1998; 124 625-630
- 249 Konstantinovic V S, Dimic N D. Articulatory function and tongue mobility after surgery followed by radiotherapy for tongue and floor of the mouth cancer patients. Br J Plast Surg. 1998; 51 589-593
- 250 Konstantinovic V S. Quality of life after surgical excision followed by radiotherapy for cancer of the tongue and floor of the mouth: evaluation of 78 patients. J Craniomaxillofac Surg. 1999; 27 192-197
- 251 Schliephake H, Schmelzeisen R, Schonweiler R, Schneller T, Altenbernd C. Speech, deglutition and life quality after intraoral tumour resection. A prospective study. Int J Oral Maxillofac Surg. 1998; 27 99-105
- 252 Hicks W L, Loree T R, Garcia R I, Maamoun S, Marshall B S, Orner J B, Bakamjian V Y, Shedd D P. Squamous cell carcinoma of the floor of mouth: a 20-years review. Head Neck. 1997; 19 400-405
- 253 Nason R W, Sako K, Beecroft W A, Razack M S, Bakamjian V Y, Shedd D P. Surgical management of squamous cell carcinoma of the floor of the mouth. Am J Surg.. 1989; 158 292-296
- 254 Sessions D G, Spector G J, Lenox J, Parriott S, Haughey B, Chao C, Marks J, Perez C. Analysis of treatment results for floor of mouth cancer. Laryngoscope. 2000; 110 1764-1772
- 255 Ikeda H, Nishiyama K, Masaki N. Squamous cell carcinoma of the floor of mouth treated by radiotherapy. Nippon Acta Radiol. 1985; 45 877-893
- 256 Marsiglia H, Haie-Meder C, Sasso G, Mamelle G, Gerbaulet A. Brachytherapie for T1- T2 floor-of-the-mouth cancer: the Gustave-Roussy Institute experience. Int J Radiat Oncol Biol Phys. 2002; 52 1257-1263
- 257 Foote R L, Schild S E, Thompson W M, Buskirk S J, Olsen K D, Stanley R J, Kunselmann S J, Schaid D J, Grill J P. Tonsil cancer. Patterns of failure after surgery alone and surgery combined with postoperative radiation therapy. Cancer. 1994; 73 2638-2647
- 258 Hicks W L, Kuriakose M A, Loree T R, Orner J B, Schwartz G, Mullins A, Donaldson C, Winston J M, Bakamjian V Y. Surgery versus radiation therapy as single-modality treatment of tonsillar fossa carcinoma: the Rosewell Park Cancer Institute experience (1971-1991). Laryngoscope. 1998; 108 1014-1019
- 259 Leemans C R, Engelbrecht W J, Tiwari R, Deville W L, Karim A B, van der Waal I, Snow G B. Carcinoma of the soft palate and anterior tonsillar pillar. Laryngoscope. 1994; 104 1477-1481
- 260 Perez C A, Patel M M, Chao K SC, Simpson J R, Sessions D, Spector G J, Haughey B, Lockett M A. Carcinoma of the tonsillar fossa: prognostic factors and long-term therapy outcome. Int J Radiat Oncol Biol Phys. 1998; 42 1077-1084
- 261 Wang M B, Kuber N, Kerner M M, Lee S P, Juilliard G F, Abemayor E. Tonsillar carcinoma: analysis of treatment results. J Otolaryngol. 1998; 27 263-269
- 262 Zelefsky M J, Harrison L B, Armstrong J G. Long-term treatment results of postoperative radiation therapy for advanced stage oropharyngeal carcinoma. Cancer. 1992; 70 2388-2395
- 263 Jackson S M, Hay J H, Flores A D, Weir L, Wong F L, Schwindt C, Baerg B. Cancer of the tonsil: the results of ipsilateral radiation treatment. Radiother Oncol. 1999; 51 123-128
- 264 Mendenhall W M, Amdur R J, Stringer S P, Villaret D B, Cassisi N J. Radiation therapy for squamous cell carcinoma of the tonsillar region: a preferred alternative to surgery?. J Clin Oncol. 2000; 18 2219-2225
- 265 Foote R L, Hilgenfeld R U, Kunselman S J. Radiation therapy for squamous cell carcinoma of the tonsil. Mayo Clin Proc. 1994; 69 525-531
- 266 Parsons J T, Mendenhall W M, Stringer S P, Amdur R J, Hinerman R W, Villaret D B, Moore-Higgs G J, Green B D, Speer T W, Cassisi N J, Million R R. Squamous cell carcinoma of the oropharynx. Surgery, radiation therapy, or both. Cancer. 2002; 94 2967-2980
- 267 DeNittis A S, Machtay M, Rosenthal D I, Sanfilippo N J, Lee J H, Goldfeder S, Chalian A A, Weinstein G S, Weber R S. Advanced oropharyngeal carcinoma treated with surgery and radiotherapy: Oncologic outcome and functional assessment. Am J Otolaryngol. 2001; 22 329-335
- 268 Steiner W, Fierek O, Ambrosch P, Hommerich C P, Kron M. Transoral laser microsurgery for squamous cell carcinoma of the base of tongue. Arch Otolaryngol Head Neck Surg. 2003; 129 36-43
- 269 Foote R L, Olsen K D, Davis D L, Buskirk S J, Stanley R J, Kunselman S J, Schaid D J, DeSanto L W. Base of tongue carcinoma: Patterns of failure and predictors of recurrence after surgery alone. Head Neck. 1993; 15 300-307
- 270 Nisi K W, Foote R L, Bonner J A, McCaffrey T V. Adjuvant radiotherapy for squamous cell carcinoma of the tongue base: Improved local-regional disease control compared with surgery alone. Int J Radiat Oncol Biol Phys. 1998; 41 371-377
- 271 Weber R S, Gidley P, Morrison W H, Peters L J, Hankins P, Wolf P, Guillamondegui O. Treatment selection for carcinoma of the base of the tongue. Am J Surg. 1990; 160 415-419
- 272 Gourin C G, Johnson J T. Surgical treatment of squamous cell carcinoma of the base of tongue. Head Neck. 2001; 23 653-660
- 273 Kraus D H, Vastola A P, Huvos A G, Spiro R H. Surgical management of squamous cell carcinoma of the base of the tongue. Am J Surg. 1993; 166 384-388
- 274 Nasri S, Oh Y, Calcaterra T C. Transpharyngeal approach to base of tongue tumors: a comparative study. Laryngoscope. 1996; 106 945-950
- 275 Brunin F, Mosseri V, Jaulerry C, Point D, Cosset J M, Rodriguez J. Cancer of the base of the tongue: Past and future. Head Neck. 1999; 21 751-759
- 276 Jaulerry C, Rodriguez J, Brunin F, Mosseri V, Pontvert D, Brugere J, Bataini J P. Results of radiation therapy in carcinoma of the base of the tongue. Cancer. 1991; 67 1532-1538
- 277 Mak A C, Morrison W H, Garden A S. Base of tongue carcinoma: Treatment results using concomitant boost radiotherapy. Int J Radiat Oncol Biol Phys. 1995; 33 289-296
- 278 Mendenhall W M, Stringer S P, Amdur R J, Hinerman R W, Moore-Higgs G, Cassisi N J. Is radiation therapy a preferred alternative to surgery for squamous cell carcinoma of the base of tongue?. J Clin Oncol. 2000; 18 35-42
- 279 Harrison L B, Zelefsky M J, Armstrong J G, Carper E, Gaynor J J, Sessions R B. Performance status after treatment for squamous cell cancer of the base of tongue - A comparison of primary radiation therapy versus primary surgery. Int J Radiat Oncol Biol Phys. 1994; 30 953-957
- 280 Moore G J, Parsons J T, Mendenhall W M. Quality of life outcomes after primary radiotherapy for squamous cell carcinoma of the base of tongue. Int J Radiat Oncol Biol Phys. 1996; 36 351-354
- 281 Robertson M L, Gleich L L, Barrett W L, Gluckman J L. Base of tongue cancer: Survival, function, and quality of life after external beam irradiation and brachytherapy. Laryngoscope. 2001; 111 1362-1365
- 282 Horwitz E M, Frazier A J, Martinez A A, Keidan R D, Clarke D H, Lacerna M D, Gustafson G S, Heil E, Dmuchowski C F, Vicini F A. Excellent functional outcome in patients with squamous cell carcinoma of the base of tongue treated with external irradiation and interstitial iodine 125 boost. Cancer. 1996; 78 948-957
- 283 Harrison L B, Lee H J, Pfister D G, Kraus D H, White C, Raben A, Zelefsky M J, Strong E W, Shah J P. Long term results of primary radiotherapy with/without neck dissection for squamous cell cancer of the base of tongue. Head Neck. 1998; 20 668-673
- 284 Vokes E E, Kies M S, Haraf D J, Stenson K, List M, Humerickhouse R, Dolan M E, Pelzer H, Sulzen L, Witt M E, Hsieh Y C, Mittal B B, Weichselbaum R R. Concomitant chemoradiotherapy as primary therapy for locoregionally advanced head and neck cancer. J Clin Oncol. 2000; 18 1652-1661
- 285 Vaughan C W, Strong M S, Jako G J. Laryngeal carcinoma: transoral resection utilizing the CO2 laser. Am J Surg. 1978; 136 490-493
- 286 Laccourreye O, Lawson G, Muscatello L, Biacabe B, Laccourreye L, Brasnu D. Carbon dioxide laser debulking for obstructing endolaryngeal carcinoma: a 10-year experience. Ann Otol Rhinol Laryngol. 1999; 108 490-494
- 287 Davis R K, Shapshay S M, Vaughan C W, Strong M S. Pretreatment airway management in obstructing carcinoma of the larynx. Otolaryngol Head Neck Surg. 1981; 89 209-214
- 288 McGuirt W F, Koufman J A. Endoscopic laser surgery. An alternative in laryngeal cancer treatment. Arch Otolaryngol Head Neck Surg. 1987; 113 501-505
- 289 Robson A K, Herrema I, Stafford F W. Laser debulking for obstructing laryngeal tumours. Clin Otolaryngol. 1994; 19 430-432
- 290 Rudert H. Larynx- und Hypopharynxkarzinome - Endoskopische Chirurgie mit dem Laser: Möglichkeiten und Grenzen. Arch Oto-Rhino-Laryngol Suppl. 1991; 1 3-18
Prof. Dr. Petra Ambrosch
Klinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie der Christian-Albrechts-Universität zu Kiel
Arnold-Heller-Straße 14 · 24105 Kiel ·
eMail: ambrosch@hno.uni-kiel.de