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Horm Metab Res 2003; 35(2): 97-103
DOI: 10.1055/s-2003-39051
Original Clinical
© Georg Thieme Verlag Stuttgart · New York

Post-Exercise Increase of Lipid Oxidation after a Moderate Exercise Bout in Untrained Healthy Obese Men

F.  Marion-Latard 1 , F.  Crampes 1 , A.  Zakaroff-Girard 1 , I.  De Glisezinski 1 , I.  Harant 1 , V.  Stich 2 , C.  Thalamas 3 , D.  Rivière 1 , M.  Lafontan 1 , M.  Berlan 1
  • 1 Institut national de la santé et de la recherche médicale (INSERM Unit 586): Department of the Adaptation to the Exercise and Laboratory of Medical and Clinical Pharmacology, Faculty of Medicine, Toulouse, France
  • 2 Department of Sport Medicine and Obesity Unit, Charles University, Prague 2, Czech Republic
  • 3 Center of Clinical investigation, Purpan Hospital, Toulouse, France
Further Information

Publication History

Received 28 February 2002

Accepted after revision 19 August 2002

Publication Date:
07 May 2003 (online)

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Abstract

The aim of the study was to examine whether a moderate exercise increases the utilization of fatty acids during the recovery period in obese men. Six healthy obese participated in a randomized crossover investigation, one with exercise and one without exercise. At 8 a. m., the subjects had a standardized breakfast and they rested in a sitting position for 3 hours. The subjects were maintained in the sitting position for 4 additional hours in one session. In a second session, they exercised for 60 min at 50 % of their V˙O2 max and then returned to the sitting position for 3 hours. Respiratory exchange ratio (RER) values were calculated by indirect calorimetry. During the resting session, plasma non-esterified fatty acids (NEFA) and glycerol concentrations rose progressively, whereas RER progressively decreased. During the exercise, plasma catecholamines, NEFA, glycerol, growth hormone and cortisol levels and RER increased while insulin decreased. During the recovery, plasma NEFA increased and glycerol decreased. During the first hour of recovery, RER values were lower and fatty acid utilization higher than during the same period of the resting session. The study shows that exercise induces modifications in hormonal factors promoting lipid mobilization and suggests that exercise provide substantial amounts of NEFA for muscle oxidation during recovery from an exercise bout in obese subjects.

Key words

Respiratory Exchange Ratio - Fat Oxidation - Exercise - Post-Exercise Recovery - Non-Esterified Fatty Acids - Lipid Mobilization - Fat Oxidation

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Dr. M. Berlan

INSERM U 586 · Laboratoire de Pharmacologie Médicale et Clinique

Faculté de Médecine · 37 Allées Jules Guesde · 31073 Toulouse cedex · France

Phone: +33(5)61145907

Fax: +33(5)612551 16 ·

Email: berlan@cict.fr