Removal of Acyl Protecting Groups Using Solid NaOH and a Phase Transfer Catalyst

Abstract

Acetyl-, benzoyl- and pivoyl-protected alcohols and phenols undergo smooth deacylation in a two-phase system of powdered NaOH and Bu₄NHSO₄ in THF or CH₂Cl₂.

protecting groups - alcohols - phase-transfer catalysis - acyl groups - deprotection

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