Planta Med 2003; 69(5): 474-476
DOI: 10.1055/s-2003-39712
Letter
© Georg Thieme Verlag Stuttgart · New York

Anti-Inflammatory Action of Legume Isoflavonoid Sophoricoside through Inhibition on Cyclooxygenase-2 Activity

Byung Hak Kim1 , Eun Yong Chung1 , Bo-Kyung Min1 , Seung Ho Lee2 , Mi-Kyeong Kim3 , Kyung Rak Min1 , Youngsoo Kim1
  • 1College of Pharmacy and Research Center for Bioresource and Health, Chungbuk National University, Cheongju, Korea
  • 2College of Pharmacy, Yeungnam University, Kyongsan, Korea
  • 3College of Medicine, Chungbuk National University, Cheongju, Korea
Further Information

Publication History

Received: September 27, 2002

Accepted: January 25, 2003

Publication Date:
12 June 2003 (online)

Abstract

Soy is a main source of isoflavonoids which are of high dietary intake for the oriental population. In this study, the anti-inflammatory action of sophoricoside, an isoflavone glycoside isolated from immature fruits of Sophora japonica L. (Leguminosae), has been demonstrated. When administered orally at > 100 mg/kg or injected intravenously at > 10 mg/kg, sophoricoside showed significant reduction of carrageenin-induced paw edema in mice. Sophoricoside has been identified as a selective inhibitor of cyclooxygenase (COX)-2 activity with an IC50 value of 3.3 μM.

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Professor Youngsoo Kim, Ph. D.

College of Pharmacy

Chungbuk National University

Cheongju 361-763

Korea

Fax: +82-43-268-2732

Email: youngsoo@cbucc.chungbuk.ac.kr