Abstract
Novel efficient synthesis of several enantio-pure 2-alkylated
1α,25-dihydroxy-19-norvitamin D3 analogues through
radical introduction of 2-alkyl chain and C5-C6 position
coupling using Julia-type olefination as key steps was established
starting from commercially available (-)-quinic
acid as a chiral pool.
Key words
total synthesis - vitamin D - radical reactions - Julia reactions - coupling
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