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Synthesis 2003(9): 1347-1356
DOI: 10.1055/s-2003-40204
DOI: 10.1055/s-2003-40204
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York
Highly Substituted Isoxazoles: The Baylis-Hillman Reaction of Substituted 4-Isoxazolecarbaldehydes and Attempted Cyclization to Isoxazole-Annulated Derivatives [1]
Further Information
Received
18 March 2003
Publication Date:
24 June 2003 (online)
Publication History
Publication Date:
24 June 2003 (online)
Abstract
In an attempt to understand the effect of position of the formyl group on the efficiency of Baylis-Hillman reaction within isoxazolecarbaldehydes, the reactions of substituted 4-isoxazolecarbaldehydes to obtain highly substituted isoxazoles are described. Attempts to obtain isoxazole-annulated derivatives from these Baylis-Hillman adducts involving SNR′-SNAr substitution strategy are also described.
Key words
Baylis-Hillman reaction - 4-isoxazolecarbaldehyde - DABCO - DMAP
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