Facile Synthesis of Carboxylic Anhydrides Using 4,5-Dichloro-2-[(4-nitro­phenyl)sulfonyl]pyridazin-3(2H)-one

Abstract

A novel and facile synthesis of carboxylic anhydrides from carboxylic acid using 4,5-dichloro-2-[(4-nitrophenyl)sulfonyl]pyridazin-3(2H)-one (2) is presented. Treatment of aliphatic or aromatic carboxylic acids with 2 in the presence of base in organic solvents gave the corresponding anhydrides in good or excellent yields

Key words

4,5-dichloro-2-[4-nitrophenyl)sulfonyl]pyridazin-3(2H)-one - carboxylic anhydride - sulfonyl-transfer

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16

Compounds 10 and 11 were synthesized from saccharin and 2-pyridone, respectively, by reacting with 4-nitrobenzene-sulfonyl chloride in the presence of Et₃N in THF according to Kweon’s Method. [14]