Synthesis of Substituted Phenyl 2-Aminopyridine-3-sulfonates

Abstract

A series of phenyl 2-aminopyridine-3-sulfonates 3 has been synthesized starting from phenyl cyanomethanesulfonate (5). Pinner reaction with 5 gave phenoxysulfonylketene aminal 4K which was cyclocondensed with a series of C₃-biselectrophiles to yield the title compounds, which are of pharmaceutical and medicinal interest.

pyridines - condensation - tautomerisation - phenoxysulfonylketene aminals - 2-aminopyridine-3-sulfonates

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