Z Gastroenterol 2003; 41(7): 667-674
DOI: 10.1055/s-2003-40543
Übersicht
© Karl Demeter Verlag im Georg Thieme Verlag Stuttgart · New York

Onkolytische Viren als innovativer Ansatz in der Therapie gastrointestinaler Tumoren

Oncolytic viruses for genetic therapy of gastrointestinal tumorsM. Bitzer1 , U. M. Lauer1
  • 1Abteilung Innere Medizin I, Medizinische Universitätsklinik, Tübingen
Weitere Informationen

Publikationsverlauf

Manuskript-Eingang: 13. August 2002

Annahme nach Revision: 17. Oktober 2002

Publikationsdatum:
14. Juli 2003 (online)

Zusammenfassung

Für die gastroenterologische Onkologie werden zusätzliche Therapiestrategien benötigt, die auf neuartigen Mechanismen basieren und keine Kreuzresistenz hinsichtlich gegenwärtiger Standardtherapien zeigen. Einen dieser Ansätze stellt die Virotherapie dar, bei der replikationskompetente virale Vektoren mit stark ausgeprägter onkolytischer Funktion zum Einsatz kommen und gegenwärtig innerhalb präklinischer und klinischer Studien evaluiert werden. Unter Einsatz der Methodik der molekularen Virologie ist eine Fortentwicklung der momentan verfügbaren Vektorsysteme insbesondere zur Verbesserung der onkolytischen Aktivität, der Tumorselektivität, der Durchwanderungsfähigkeit von Tumoren sowie der Sicherheitsaspekte erforderlich.

Abstract

Gastroenterological oncology requires new strategies with new mechanisms of action and without cross-resistance to currently available treatment regimes. Virotherapy which is based on the employment of replication-competent viral vectors exhibiting strong oncolytic properties is such an approach currently under preclinical/clinical investigation. Techniques of molecular virology are required for further improvement of current vectors, particularly with respect to oncolytic activity, tumour selectivity, tumour spread capacity, and safety.

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PD Dr. med. Ulrich M. Lauer

Abteilung Innere Medizin I, Medizinische Universitätsklinik, Universitätsklinikum Tübingen

Otfried-Müller-Straße 10

72076 Tübingen

eMail: ulrich.lauer@uni-tuebingen.de