Planta Med 2003; 69(6): 542-546
DOI: 10.1055/s-2003-40637
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

Furoquinoline Alkaloids and Cytotoxic Constituents from the Leaves of Melicope semecarpifolia

Jih-Jung Chen1 , Chang-Yih Duh2 , Hung-Yi Huang1 , Ih-Sheng Chen3
  • 1Department of Pharmacy, Tajen Institute of Technology, Pingtung, Taiwan, Republic of China
  • 2Institute of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China
  • 3School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China
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Publikationsverlauf

Received: October 17, 2002

Accepted: February 15, 2003

Publikationsdatum:
16. Juli 2003 (online)

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Abstract

Three new furoquinoline alkaloids, melicarpine, semecarpine, and (±)-8-methoxyplatydesmine, together with a known flavone, ayanin, were isolated from the leaves of Melicope semecarpifolia. The structures of the three alkaloids were determined through spectral analyses. Of the nineteen isolates obtained here and during earlier work, twelve exhibited cytotoxic activity against P-388, HT-29, or A549 cell lines in vitro. Among them, confusameline is the most cytotoxic isolate, and exhibited more potent cytotoxicity (ED50 value = 0.03 μg/mL) against the P-388 cell line than the reference compound mithramycin (ED50 value = 0.06 μg/mL).

References

Prof. Dr. I. S. Chen

School of Pharmacy

Kaohsiung Medical University

Kaohsiung

Taiwan

Republic of China

eMail: m635013@kmu.edu.tw

Fax: +886-7-3210683