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DOI: 10.1055/s-2003-40649
Antiviral Activity of N-Benzoylphenylisoserinates of Lactarius Sesquiterpenoid Alcohols in vitro
Publikationsverlauf
Received: October 16, 2002
Accepted: March 8, 2003
Publikationsdatum:
16. Juli 2003 (online)
![](https://www.thieme-connect.de/media/plantamedica/200306/lookinside/thumbnails/10.1055-s-2003-40649-1.jpg)
Abstract
Cytotoxic, antiviral, antibacterial and antifungal properties of a new, originally synthesised group of compounds: the N-benzoylphenylisoserinates of sesquiterpenoid alcohols - derivatives of taxol and various sesquiterpenes of Lactarius origin were evaluated in vitro. Among 16 compounds tested, 6 decreased HSV-1 titres. Selectivity indices ranged from 13.9 to 31.7. No activity against RNA viruses (parainfluenza 3, Coxsackie B3, vesicular stomatitis virus, and encephalomyocarditis virus), bacteria: Escherichia coli, Proteus mirabilis, Staphylococcus aureus, Enterococcus faecium and Bacteroides fragilis and fungal strain of Candida albicans was detected.
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Dr. Ewa Krawczyk
Chair and Department of Medical Microbiology
Medical University of Warsaw
5 Chalubinski St
02-004 Warsaw
Poland
Telefon: +48-22-6220028
Fax: +48-22-6282739
eMail: ewakrawczyk@gazeta.pl