A Concise Building Block Approach to a Diverse Multi-Arrayed Library of the Circumdatin Family of Natural Products

Abstract

Using a polymer-supported phosphine-mediated intramolecular aza-Wittig reaction in a key step of a reaction sequence a diverse library of benzodiazepine-quinazolinone alkaloids (Circumdatins) has been prepared using a novel modified Eguchi protocol. The multi-arrayed library generation strategy commenced from readily accessible benzodiazepinedione derivatives (and anthranilic acids) and all library members were purified by reverse phase preparative HPLC.

aza-Wittig reaction - polymer supported triphenylphosphine - natural product libraries - privileged scaffolds

References

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