Noninvasive Assessment of Neoplastic Angiogenesis: The Role of Magnetic Resonance Imaging

Majed Abu-Hajir; Scott D. Rand; Hendrikus G. Krouwer; Kathleen M. Schmainda

doi:10.1055/s-2003-40969

Seminars in Thrombosis and Hemostasis, Table of Contents

Semin Thromb Hemost 2003; 29(3): 309-316
DOI: 10.1055/s-2003-40969

Noninvasive Assessment of Neoplastic Angiogenesis: The Role of Magnetic Resonance Imaging

Majed Abu-Hajir¹ , Scott D. Rand² , Hendrikus G. Krouwer³ , Kathleen M. Schmainda^2,4

¹Assistant Professor of Medicine, Division of Neoplastic Diseases and Related Disorders, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin
²Department of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin
³Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin
⁴Biosphysics Research Institute, Medical College of Wisconsin, Milwaukee, Wisconsin

Abstract

ABSTRACT

The study of the effect of angiogenesis inhibitors on tumors is limited by our ability to assess their effect in vivo. Approaches that are currently employed have significant limitations. An ideal approach would employ a widely available noninvasive technology that can be used repeatedly to assess the antiangiogenic effect on the same lesions in a serial fashion. We describe here a specialized magnetic resonance imaging (MRI)-based technique that we employ in the study of angiogenesis of brain tumors. This technique, called relative cerebral blood volume (rCBV) mapping, is a noninvasive technique that adds just a few minutes to the conventional MRI study of a human brain tumor in the clinical setting. We hope that such a technique will serve as a model for developing new imaging techniques for the assessment of angiogenesis modulation in other tumor settings. We describe the technical basis and some examples of using rCBV mapping in neoplastic angiogenesis assessment, including a discussion of current limitations and future directions.

KEYWORDS

Angiogenesis - magnetic resonance imaging - tumor imaging - glioblastoma multiforme

Full Text

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