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Synthesis 2003(15): 2298-2300
DOI: 10.1055/s-2003-41070
DOI: 10.1055/s-2003-41070
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York
Vanadium(III) Chloride-Catalyzed Preparation of β-Amino Alcohols from Epoxides
Further Information
Received
26 May 2003
Publication Date:
25 September 2003 (online)
Publication History
Publication Date:
25 September 2003 (online)
Abstract
Vanadium(III) chloride was found to catalyze the cleavage of epoxides with aromatic amines in an efficient way to afford the corresponding β-amino alcohols in very good yields. The reactions are completely anti-stereoselective, highly regioselective and proceed at room temperature.
Key words
epoxides - amines - VCl3 - amino alcohols
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