RSS-Feed abonnieren
DOI: 10.1055/s-2003-41118
Antibacterial New Clerodane Diterpenes from the Surface of Haplopappus foliosus
Publikationsverlauf
                     Received: September 12, 2002
                     
                     Accepted: March 29, 2003
                     
Publikationsdatum:
04. August 2003 (online)
Abstract
A biologically monitored fractionation of the resinous exudate extract of Haplopappus foliosus DC. is reported. Purification of the two active fractions yielded 2-α-hydroxy-cis-cleroda-3,13(Z),8(17)-trien-15-oic acid (1) and 2-α-acetoxy-cis-cleroda-3,13(Z),8(17)-trien-15-oic acid (2), two new clerodane diterpenes.
References
- 1 Farga C, Lastra J. Plantas medicinales de uso común en Chile. Vol. I Santiago de Chile; Soprami 1988: p. 11
 - 2 Urzúa A, Mendoza L. Antibacterial activity of the resinous exudates from Haplopappus uncinatus and Haplopappus foliosus . Fitoterapia. 2001; 72 418-20
 - 3 Tori M, Katto A, Sono M. Nine new clerodane diterpenoids from rhizomes of Solidago altissima . Phytochemistry. 1999; 52 487-93
 - 4 Avila D, Medina J D, Deeming A J. New clerodane type diterpenoid from Eperua leucantha . J Nat Prod. 1992; 55 845-50
 - 5 Rezende M C, Urzúa A, Bortoluzzi A J, Vásquez L. Variation of the antimicrobial activity of Pseudognaphalium vira vira (Asteraceae): isolation and X-ray structure of ent-3β-hydroxy-16-kauren-19-oic acid. J Ethnopharmacol. 2000; 72 459-64
 - 6 Wilkens M, Alarcón C, Urzúa A, Mendoza L. Characterization of the bactericidal activity of the natural diterpene kaurenoic acid. Planta Med. 2002; 68 452-4
 - 7 Urzúa A, Rezende M C, Vásquez L, Mendoza L, Wilkens M, Tojo E. Antimicrobial study of the resinous exudate and diterpenoids isolated from Eupatorium salvia (Asteraceae). J Ethnopharmacol. 1998; 62 251-4
 - 8 Urzúa A, Andrade L, Jara F. Comparative leaf surface chemistry from Haplopappus foliosus and Haplopappus uncinatus . Biochem Syst Ecol. 2000; 28 491
 - 9 Urzúa A, Modak B, Villarroel L, Torres R, Andrade L. Comparative flavonoid composition of the resinous exudates from Heliotropium Chenopodiaceum var. ericoideum and H. chenopodiaceum var. chenopodiaceum . Biochem Syst Ecol. 1998; 26 127-30
 - 10 Mayr-Harting A, Hedges A, Berkeley R (eds.). Methods for studying bacteriocins. New York; Academic Press 1972: p. 74
 - 11 Ausubel F, Brent R, Kingston R E, Moore D D, Seidman J G. Short protocols in Molecular Biology. New York; John Wiley and Sons 1999: pp. 1-3
 - 12 Murray P, Baron E J, Pfaller M A, Tenover F C, Yolken R H. Manual of Clinical Microbiology. Washington DC; American Society for Microbiology 1999: p. 1.105
 - 13 Prescott L M, Harley P J, Klein D A. Microbiología. 4th Edn Mexico; McGraw-Hill Interamericana 1999: p. 760
 
Prof. Dr. René Torres
         Department of Basic Chemistry
         
         University of Santiago of Chile
         
         Casilla 40
         
         Correo 33
         
         Santiago of Chile
         
         Chile
         
         eMail: aurzuamoll44@yahoo.com
         
         
    
      
    