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Planta Med 2003; 69(7): 662-666
DOI: 10.1055/s-2003-41123
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

Sesquiterpenes and Other Constituents from the Aerial Parts of Inula japonica

Chao Yang1 , Chun-Ming Wang1 , Zhong-Jian Jia1
  • 1Department of Chemistry, National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, People's Republic of China
This work was supported by the National Natural Science Foundation of China NO. 29972017.
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Publikationsverlauf

Received: November 27, 2002

Accepted: April 12, 2003

Publikationsdatum:
04. August 2003 (online)

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Abstract

Three new sesquiterpenes, 1β-hydroxy-8β-acetoxycostic acid methyl ester, 1β-hydroxy-8β-acetoxyisocostic acid methyl ester and 1β-hydroxy-4α,11α-eudesma-5-en-12,8β-olide, along with fourteen known compounds were isolated from the aerial parts of Inula japonica. The structures of these new compounds were elucidated by spectroscopic methods (IR, EIMS, HRMS, 1D and 2D NMR). 1,6α-dihydroxy-4αH-1,10-secoeudesma-5(10),11(13)-dien-12,8β-olide exhibited appreciable cytotoxic activity against cultured SMMC-7721 (human hepatoma cell) and HO-8910 (human ovarian carcinoma cell) with IC50 values of 52.22 and 21.32 μg/mL, while 5αH-eudesma-4(15),11(13)-dien-12,8β-olide showed remarkable cytotoxic activity against cultured SMMC-7721 and HO-8910 with IC50 values of 6.21 and 5.28 μg/mL, respectively.

Key words

Inula japonica - Compositae - sesquiterpene - eudesmane - cytotoxic activity

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Prof. Zhong-Jian Jia

Department of Chemistry

Lanzhou University

Lanzhou

Gansu 730000

Peoples Republic of China

Fax: +86-0931-8912582

eMail: Jiazj@lzu.edu.cn