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DOI: 10.1055/s-2003-41126
Aporphine Alkaloids from Guatteria spp. with Leishmanicidal Activity
This work was supported by US NIH grant #1U01 TW01021-01 from the International Cooperative Biodiversity Groups program ICBG.Publication History
Received: October 29, 2002
Accepted: March 29, 2003
Publication Date:
04 August 2003 (online)
Abstract
Fractionation of Guatteria amplifolia yielded the alkaloids xylopine (1), nornuciferine (4), lysicamine (6), and laudanosine (5). Fractionation of Guatteria dumetorum yielded the alkaloids cryptodorine (2) and nornantenine (3). Compounds 1 - 4 demonstrated significant activity against Leishmania mexicana and L. panamensis. Xylopine (1) was among the most active compounds (LD50 = 3 μM) and showed a 37-fold higher toxicity towards L. mexicana than macrophages, the regular host cells of Leishmania spp.
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Dr. Luis Cubilla Rios
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Universidad de Panamá
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