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Semin Reprod Med 2003; 21(2): 119-124
DOI: 10.1055/s-2003-41318
Copyright © 2003 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Genomics' Role in Understanding the Pathogenesis of Endometriosis

Linda C. Giudice
  • Division of Reproductive Endocrinology Infertility, Department of Gynecology Obstetrics, Stanford University School of Medicine Stanford, California
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Publication History

Publication Date:
14 August 2003 (online)

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ABSTRACT

Endometriosis is a benign, estrogen-dependent disorder that has multifactorial components presumed in its pathogenesis. The molecular mechanisms underlying endometrial tissue attachment to the peritoneal surface or metaplasia of the mesothelium, and subsequent invasion and establishment of a blood supply and survival of the endometriotic implants, are not well understood. Recent advances in molecular biology and genomics suggest an intrinsic abnormality in the eutopic endometrium of women with endometriosis that predisposes to these processes. These are discussed herein.

KEYWORDS

Genomics - proteomics - endometrium - implantation - endometriosis

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