Mining Sequence Space for Asymmetric Aminocatalysis: N-Terminal Prolyl-Peptides Efficiently Catalyze Enantioselective Aldol and Michael Reactions

Abstract

N-Terminal prolyl-peptides efficiently catalyze asymmetric aldol and Michael reactions between acetone and p-nitro­benzaldehyde or β-nitrostyrene, respectively.

organocatalysis - enamine catalysis - aminocatalysis - peptides

References

1

New Address: Max-Plank-Institut für Kohlenforschung, 45470 Mülheim an der Ruhr, Germany.
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12 After this manuscript has been accepted for publication, related results were reported by: Kofoed J. Nielsen J. Reymond J.-L. Bioorg. Med. Chem. Lett.  2003,  13:  2445