Z Gastroenterol 2003; 41(9): 921-928
DOI: 10.1055/s-2003-41824
Übersicht
© Karl Demeter Verlag im Georg Thieme Verlag Stuttgart · New York

Neue endoskopische Therapieverfahren bei gastroösophagealer Refluxkrankheit

New Endoscopic Therapies for Gastroesophageal Reflux DiseaseM. Bittinger1 , H. Messmann1
  • 1III. Medizinische Klinik, Klinikum Augsburg
Further Information

Publication History

Manuskript-Eingang: 23. Oktober 2002

Annahme nach Revision: 11. Februar 2003

Publication Date:
17 September 2003 (online)

Zusammenfassung

Die bisherige, ständig wachsende Datenlage zu den neuen endoskopischen Refluxtherapieverfahren lässt hoffen, dass sich mit diesen neuen Therapiekonzepten ein Teil der Patienten mit gastroösophagealer Refluxkrankheit wirksam behandeln lässt. Allerdings ist derzeit nicht klar, welches der Verfahren sich durchsetzen wird. Randomisierte Studien zum Vergleich der Verfahren untereinander und insbesondere auch zum Vergleich gegen den bisherigen Goldstandard für die interventionelle Refluxtherapie (laparoskopische Fundoplikatio) sind erforderlich. Zudem müssen weitere Daten insbesondere die Langzeiteffektivität dieser neuen Therapieformen belegen, bevor sie Teil der Standardtherapie werden können.

Abstract

The growing data about new endoscopic therapies for gastroesophageal reflux disease (GERD) seem to indicate that these techniques might be effective at least in a part of patients suffering from GERD. However, up to now it is not clear which technique is the best. Randomized studies comparing the different techniques with each other and especially with surgical antireflux procedures (laparoscopic fundoplicatio) are needed. In addition, more data proving the long term effectiveness of these new techniques are necessary.

Literatur

  • 1 Locke G, Talley N, Fett S. et al . Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Olmsted County, Minnesota.  Gastroenterology. 1997;  112 1448-1452
  • 2 Sonnenberg A, El-Serag H. Epidemiology of gastroesophageal reflux disease. Büchler MW, Frei E, Klaiber C et al Gastroesophageal reflux disease (GERD): Back to surgery Prog Surg 1997 23: 20-26
  • 3 Lagergren J, Bergstrom R, Lindgren A. et al . Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma.  New Engl J Med. 1999;  340 825-831
  • 4 Lee J, O'Morain C. Trends in the management of gastro-esophageal reflux disease.  Postgrad Med. 1998;  74 145-150
  • 5 Terry M, Smith C, Branum G. et al . Outcomes of laparoscopic fundoplication for gastroösophageal reflux disease and paraesophageal hernia.  Surg Endosc. 2001;  15 691-699
  • 6 Laine S, Rantala A, Gullichsen R. et al . Laparoscopic versus conventional fundoplication.  Sruc Endosc. 1997;  11 441-444
  • 7 Spechler S, Lee E, Ahnen D. et al . Long-term outcome of medical and surgical therapies for gastroesophageal reflux disease: follow-up of a randomized controlled trial.  JAMA. 2001;  285 2331-2338
  • 8 Fingerhut A, Millat B, Etienne J. et al .Failure and pitfalls of laparoscopic nissen repair. Büchler MW, Frei E, Klaiber C et al Gastroesophageal reflux disease (GERD): Back to surgery Prog Surg 1997 23: 158-166
  • 9 Perkidis G, Hinder R, Lund R. et al . Laparoscopic Nissen fundoplication: where do we stand?.  Surg Laparosc Endosc. 1997;  7 17-21
  • 10 Swain C. Endoscopic suturing.  Ballière’s Clinical Gastroenterology. 1999;  13 97-108
  • 11 Filipi C, Lehman G, Rothstein R. et al . Transoral, flexible endoscopic suturing for treatment of GERD: a multicenter trial.  Gastrointest Endosc. 2001;  51 416-422
  • 12 Park P, Kjellin T, Kadirkamanthan S. et al . Results of endoscopic gastroplasty for gastrooesophageal reflux disease.  Gastrointest Endosc. 2001;  53 AB 115
  • 13 Raijman I, Ben-Menachem T, Starpoli A. et al . Endoluminal gastroplication (ELGP) improves GERD symtoms in patients with large hiatal hernias.  Gastrointest Endosc. 2002;  55 AB 255
  • 14 Rothstein R, Pohl H, Growe M. et al . Endoscopic gastric plication for the treatment of GERD: Two year follow-up results.  Am J Gastroenterol. 2001;  96 S 35
  • 15 Chen Y, Rajiman I, Ben-Menachem T. et al . One-year follow up of endoluminal gastroplication (ELGP): Clinical and economic outcomes of the U.S. multicenter trial.  Gastrointest Endosc. 2002;  55: AB 109
  • 16 Rajiman I, Walters R, Garza C. et al . Helical endoluminal gastroplication (ELGP) compared to standard ELGP in patients with gastroesophageal reflux disease (GERD).  Gastrointest Endosc. 2002;  55 AB 260
  • 17 Lehman G, Dunne D, Hieston K. et al . Suturing plication of cardia with endocinch device: Effect of supplemental cautery. A human prospective randomized trial.  Gastrointest Endosc. 2002;  55: AB 260
  • 18 Mahmood Z, Byrner P, McCullough J. et al . A comparison of Bard Endocinch transoesophageal endoscopic placation (BETEP) with laparoscopic nissen fundoplication (LNF) for the treatment of gastroesophageal reflux disease (GORD).  Gastrointest Endosc. 2002;  55 AB 89
  • 19 Chuttani R, Kozarek R, Critchlow J. et al . A novel endoscopic full-thickness plicator for treatment of GERD: an animal model study.  Gastrointest Endosc. 2002;  56 116-122
  • 20 Chuttani R, Sud R, Sachdev G. et al . Endoscopic full-thickness plication for GERD: Final results of human pilot study.  Gastrointest Endosc. 2002;  55 AB 258
  • 21 Devière J, Pastorelli A, de Maertelaer V. et al . Endoscopic implantation of a biopolymer in the lower esophageal sphincter for gastroesophageal reflux: a pilot study.  Gastrointest Endosc. 2002;  55 335-341
  • 22 Lehman G, Aisenberg J, Cohen L. et al . Enteryx Solution, a minimally invasive injectable treatment for GERD: international multicenter trial results.  Gastrointest Endosc. 2002;  55 AB 97
  • 23 Fockens P, Bruno M, Hirsch D. et al . Endoscopic augmentation of the lower esophageal sphincter. Pilot study with the gatekeeper reflux repair system in patients with GERD.  Gastrointest Endosc. 2002;  55 AB 257
  • 24 Fockens P, Costamagna G, Gabbrielli A. et al . Endoscopic augmentation of the lower esophageal sphincter (LES) for the treatment of GERD: Multicenter study of the gatekeeper reflux repair system.  Gartointest Endosc. 2002;  55 AB 89
  • 25 Bittinger M, Barnert J, Wienbeck M. Pathogenesis of Gastroesophageal reflux disease. Büchler MW, Frei E, Klaiber C et al Gastroesophageal reflux disease (GERD): Back to surgery Prog Surg 1997 Vol 23: 1-8
  • 26 Triadafilopoulos G, DiBaise J, Nostrant T. et al . Radiofrequency energy delivery to the gastroesophageal junction for the treatment of GERD.  Gastrointest Endosc. 2001;  53 407-415
  • 27 Triadafilopoulos G, DiBaise J, Nostrant T. et al . The Stretta procedure for the treatment of GERD: 6 and 12 month follow-up of the U.S. open label trial.  Gastrointest Endosc. 2002;  55 149-156
  • 28 Fleischer D. The Stretta procedure: Technique optimization and complication rates.  Gastrointest Endosc. 2002;  55 AB 256
  • 29 Noar M, Knight S, Bidlack D. Long term experience with the Stretta procedure in medically refractory GERD patients: The first 14 months.  Gastrointest Endosc. 2002;  55 AB 255
  • 30 Wolfsen H. Stretta procedure patient registry: Gastroesophageal reflux disease (GERD) symptom scores, patient satisfaction and medication use in 560 patients.  Gastrointest Endosc. 2002;  55 AB 113
  • 31 Corley D, Katz P, Wo J. et al . Radiofrequency energy to the gastroesophageal junction for treatment of GERD (the Stretta procedure): A randomized, sham-controlled, multi-center clinical trial.  Gastrointest Endosc. 2002;  55 AB 100
  • 32 DiBaise J, Brand R, Quigley E. Endoluminal delivery of radiofrequency energy to the gastroesophageal junction in uncomplicated GERD : Efficacy and potential mechanism of action.  Am J Gastroenterol. 2002;  97 833-842
  • 33 Richards W, Scholz S, Khaitan L. et al . Initial experience with the Stretta procedure for the treatment of gastroesophageal reflux disease.  J Laparoendosc Adv Surg Tech. 2001;  11 267-273

PD Dr. H. Messmann

III. Medizinische Klinik,
Klinikum Augsburg

Stenglinstraße 2

86156 Augsburg