Temporal Parenteral Nutrition in Children Causing T1 Shortening in the Anterior Pituitary Gland and Globus Pallidus

H. Suzuki; J. Takanashi; N. Saeki; Y. Kohno

doi:10.1055/s-2003-42211

Neuropediatrics, Inhaltsverzeichnis

Neuropediatrics 2003; 34(4): 200-204
DOI: 10.1055/s-2003-42211

Original Article

Georg Thieme Verlag Stuttgart · New York

Temporal Parenteral Nutrition in Children Causing T₁ Shortening in the Anterior Pituitary Gland and Globus Pallidus

H. Suzuki¹ , J. Takanashi¹ , N. Saeki² , Y. Kohno¹

¹Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan
²Department of Neurosurgery, Graduate School of Medicine, Chiba University, Chiba, Japan

Abstract

Patients receiving long-term parenteral nutrition (PN) with trace elements (TE) may exhibit T₁ shortening in the anterior pituitary gland and basal ganglia. The purposes of this study were to clarify at what time or from what site the signal change begins in children. Retrospective analysis of magnetic resonance imaging results was performed for 10 pediatric patients aged from 1 to 16 years receiving temporal PN, eight of which received PN with TE for less than two months, and 13 patients with headache or seizures as age-matched controls. Axial and sagittal T₁-weighted images were obtained to analyze the T₁ shortening in the anterior pituitary gland and globus pallidus. All eight patients receiving PN with TE exhibited T₁ shortening in the anterior pituitary gland (six patients) and/or globus pallidus (five patients). No T₁ shortening was observed in the other two patients without TE, or the 13 age-matched controls. Therefore, the signal change may be associated with TE administration, and begins markedly earlier than previously reported. We discussed the possibility that manganese (Mn) caused the signal change, and proposed that the administration of a lower dose of Mn is recommended, even in the case of temporal PN, to prevent possible Mn toxicity toward both the brain and liver.

Key words

Magnetic resonance imaging - child - pituitary gland - globus pallidus - manganese

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M. D. Jun-ichi Takanashi

Department of Pediatrics · Graduate School of Medicine · Chiba University

1 - 8 - 1 Inohana, Chuo-ku, Chiba-shi

Chiba 260-8677

Japan

eMail: jtaka@med.m.chiba-u.ac.jp