Synthesis of Biaryl, Arylamine and Aryl Ketone Compounds Using a Commercially Available Air- and Moisture-Stable Palladium Catalyst

Abstract

A commercially available palladium complex bearing a N-heterocyclic carbene (NHC) was used in gram-scale synthesis of three compounds, a biaryl, an arylamine and an aryl ketone. The syntheses were performed in catalytic fashion using a Suzuki-Miyaura, a Buchwald-Hartwig and a ketone arylation reaction protocol. These three reactions were carried out using the same palladium pre-catalyst.

N-heterocyclic carbene - palladium - cross-coupling - ketone arylation - Suzuki-Miyaura coupling - aryl-amination

References

1

Visiting student from the Université Pierre et Marie Curie.

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Complex 1 is now commercially available from Strem Chemicals Inc.

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