Abstract
The structure of the quinolinone obtained from thermal cyclization of ketene dithioacetal has been revised by X-ray crystallographic analysis as 4-quinolinone instead of the previously reported 2-quinolinone. In the course of study on the mechanistic feature of the thermal cyclization, highly substituted β-lactams were obtained by alkylating β-lactam anion with MEMCl, MOMCl, or MeI in the presence of NaH.
Key words
thermal cyclization - ketene dithioacetal - β-lactam - 4-quinolinone
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