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Synthesis 2004(1): 23-25
DOI: 10.1055/s-2003-42490
DOI: 10.1055/s-2003-42490
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New YorkPalladium-Catalyzed Cyanation Reactions of Thiophene Halides
Weitere Informationen
Received
20 October 2003
Publikationsdatum:
17. November 2003 (online)
Publikationsverlauf
Publikationsdatum:
17. November 2003 (online)
Abstract
The described method provides an efficient cyanation reaction of thiophene halides using tris(dibenzylidene-acetone)dipalladium(0), 1,1′-bis-(diphenylphosphino)ferrocene) and zinc powder as the catalyst system and Zn(CN)2 as the cyanide source. Several thiophenes with various substituents are effectively cyanated under these conditions.
Key words
nitriles - thiophene - palladium - catalysis - cyanation
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