Cholesterol Trafficking and Amyloid Beta Peptides

W. G. Wood; U. Igbavboa

doi:10.1055/s-2003-43057

Pharmacopsychiatry, Inhaltsverzeichnis

Pharmacopsychiatry 2003; 36: 144-148
DOI: 10.1055/s-2003-43057

Original Paper

Cholesterol Trafficking and Amyloid Beta Peptides

W. G. Wood¹ , U. Igbavboa¹

¹Geriatric Research, Education and Clinical Center, VA Medical Center and Department of Pharmacology, University of Minnesota School of Medicine, Minneapolis, MN, USA

Abstract

Currently, there is much interest in the association between cholesterol and Alzheimer's disease. An especially important aspect of this association is the relationship between amyloid beta-peptide (Aß) and cholesterol that can be described as a reciprocal process. It would appear that cholesterol levels modulate Aß levels and in turn Aß acts on cholesterol homeostasis. Herein, we give a brief overview of amyloid beta peptide effects cellular cholesterol trafficking and potential mechanisms of those effects. Alterations of cholesterol homeostasis can have pronounced consequences on cell structure and function and may be both a cause and casualty of Alzheimer's disease.

Volltext

Referenzen

References

1 Agranoff B W. Lipids. Basic Neurochemistry: Molecular, Cellular, and Medical Aspects. Edited by Siegel G, Agranoff B, Albers RW, and Molinoff P New York; Raven Press, Ltd. 1989: pp. 91-107
2 Avdulov N A, Chochina S V, Igbavboa U, Vassiliev A V, Wood W G. Lipid binding to amyloid ß-peptide: Preferential binding of cholesterol as compared with phosphatidylcholine and fatty acids. J Neurochem. 1997; 69 1746-1752
3 Avdulov N A, Chochina S V, Igbavboa U, Wood W G. Cholesterol efflux to high density lipoproteins and apolipoprotein A - I phosphatidylcholine complexes is inhibited by ethanol: Role of apolipoprotein structure and cooperative interaction of phosphatidylcholine and cholesterol. Biochemistry. 2000; 39 10599-10606
4 Beffert U, Aumont N, Dea D, Lussier-Cacan S, Davignon J, Poirier J. ß-amyloid peptides increase the binding and internalization of apolipoprotein E to hippocampal neurons. J Neurochem. 1998; 70 1458-1466
5 Berlett B S, Stadtman E R. Protein oxidation in aging, disease, and oxidative stress. J Biol Chem. 1997; 272 20313-20316
6 Brown D A, London E. Structure and function of sphingolipid- and cholesterol-rich membrane rafts. J Biol Chem. 2000; 275 17221-17224
7 Burns M, Duff K. Cholesterol in Alzheimer's disease and tauopathy. Ann NY Acad Sci. 2002; 977 367-375
8 Butterfield D A, Griffin S, Munch G, Pasinetti G M. Amyloid beta-peptide and amyloid pathology are central to the oxidative stress and inflammatory cascades under which Alzheimer's disease brain exists. J Alzheimers Dis. 2002; 4 193-201
9 Butterfield D A, Hensley K, Harris M, Mattson M P, Carney J. ß-amyloid peptide free radical fragments initiate synaptosomal lipoperoxidation in a sequence-specific fashion: Implication to Alzheimer's disease. Biochem Biophys Res Commun. 1994; 200 710-715
10 Corrigan F M, Horrobin D F, Skinner E R, Besson J A O, Cooper M B. Abnormal content of n-6 and n-3 long-chain unsaturated fatty acids in the phosphoglycerides and cholesterol esters of parahippocampal cortex from Alzheimer's disease patients and its relationship to acetyl CoA content. International Journal of Biochemistry & Cell Biology. 1998; 30 197-207
11 Eckert G P, Igbavboa U, Müller W E, Wood W G. Lipid rafts of purified mouse brain synaptosomes prepared with or without detergent reveal different lipid and protein domains. Brain Res. 2003; 962 144-150
12 Esterbauer H, Schaur R J, Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malondialdehyde and related aldehydes. Free Radic Biol Med. 1991; 11 81-128
13 Fielding C J, Fielding P E. Molecular physiology of reverse cholesterol transport. J Lipid Res. 1995; 36 211-228
14 Fukumoto H, Deng A, Irizarry M C, Fitzgerald M L, Rebeck G W. Induction of the cholesterol transporter ABCA1 in CNS cells by LXR agonists increases secreted Aß levels. J Biol Chem. 2002; 277 48508-48513
15 Haidar B, Mott S, Boucher B, Lee C Y, Marcil M, Genest Jr J. Cellular cholesterol efflux is modulated by phospholipid-derived signaling molecules in familial HDL deficiency/Tangier disease fibroblasts. J Lipid Res. 2001; 42 249-257
16 Heino S, Lusa S, Somerharju P, Ehnholm C, Olkkonen V M, Ikonen E. Dissecting the role of the Golgi complex and lipid rafts in biosynthetic transport of cholesterol to the cell surface. Proc Natl Acad Sci USA. 2000; 97 8375-8380
17 Hooper N M. Detergent-insoluble glycosphingolipid/cholesterol-rich membrane domains, lipid rafts and caveolae (Review). Mol Mem Biol. 1999; 16 145-156
18 Igbavboa U, Pidcock J M, Johnson L NA, Malo T M, Studniski A, Sun G Y, Wood W G. Cholesterol distribution in the Golgi complex of DITNC1 astrocytes is differentially altered by fresh and aged amylodi beta-peptide_{1 - 42} . J Biol Chem. 2003; 218 17150-17151
19 Janciauskiene S, Wright H T, Lindgren S. Fibrillar Alzheimer's amyloid peptide Abeta (1 - 42) stimulates low density lipoprotein binding and cell association, free radical production and cell cytotoxicity in PC12 cells. Neuropeptides. 1999; 33 510-516
20 Koudinov A R, Koudinova N V, Berezov T T. Alzheimer's peptides Aß1 - 40 and Aß1 - 28 inhibit the plasma cholesterol esterification rate. Biochem Mol Biol Int. 1996; 38 747-752
21 Liu Y, Peterson D A, Schubert D. Amyloid ß peptide alters intracellular vesicle trafficking and cholesterol homeostasis. Proc Natl Acad Sci USA. 1998; 95 13266-13271
22 Maekawa S, Sato C, Kitajima K, Funatsu N, Kumanogoh H, Sokawa Y. Cholesterol-dependent localization of NAP-22 on a neuronal membrane microdomain (Raft). J Biol Chem. 1999; 274 21369-21374
23 Mark R J, Pang Z, Geddes J W, Uchida K, Mattson M P. Amyloid beta-peptide impairs glucose transport in hippocampal and cortical neurons: Involvement of membrane lipid peroxidation. J Neurosci. 1997; 17 1046-1054
24 Mason R P, Jacob R F, Walter M F, Mason P E, Avdulov N A, Chochina S V, Igbavboa U, Wood W G. Distribution and fluidizing action of soluble and aggregated amyloid beta-peptide in rat synaptic plasma membranes. J Biol Chem. 1999; 274 18801-18807
25 Megias L, Guerri C, Fornas E, Azorin I, Bendala E, Sancho-Tello M, Duran J M, Tomas M, Gomez-Lechon M J, Renau-Piqueras J. Endocytosis and transcytosis in growing astrocytes in primary culture. Possible implications in neural development. Int J Dev Biol. 2000; 44 209-221
26 Mendez A J. Monensin and brefeldin A inhibit high density lipoprotein-mediated cholesterol efflux from cholesterol-enriched cells: Implications for intracellular cholesterol transport. J Biol Chem. 1995; 270 5891-5900
27 Michikawa M, Gong J-S, Fan Q-W, Sawamura N, Yanagisawa K. A novel action of Alzheimer's amyloid ß-protein (Aß): Oligomeric Aß promotes lipid release. J Neurosci. 2001; 18 7226-7235
28 Montine T J, Huang D Y, Valentine W M, Amarnath V, Saunders A, Weisgraber K H, Graham D G, Strittmatter W J. Crosslinking of apolipoprotein E by products of lipid peroxidation. J Neuropathol Exp Neurol. 1996; 55 202-210
29 Nichols B J, Lippincott-Schwartz J. Endocytosis without clathrin coats. Trends Cell Biol. 2001; 11 406-412
30 Orsó E, Broccardo C, Kaminski W E, Bottcher A, Liebisch G, Drobnik W, Gotz A, Chambenoit O, Diederich W, Langmann T, Spruss T, Luciani M F, Rothe G, Lackner K J, Chimini G, Schmitz G. Transport of lipids from Golgi to plasma membrane is defective in Tangier disease patients and ABC1-deficient mice. Nature Genet. 2000; 24 192-196
31 Pierini L M, Maxfield F R. Flotillas of lipid rafts fore and aft. PNAS. 2001; 98 9471-9473
32 Refolo L M, Pappolla M A, Malester B, LaFrancois J, Bryant-Thomas T, Wang R, Tint G S, Sambamurti K, Duff K. Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model. Neurobiology of Disease. 2000; 7 321-331
33 Rothblat G H, Llera-Moya de la M, Atger V, Kellner-Weibel G, Williams D L, Phillips M C. Cell cholesterol efflux: Integration of old and new observations provides new insights. J Lipid Res. 1999; 40 781-796
34 Santamarina-Fojo S, Remaley A T, Neufeld E B, Brewer H B Jr. Regulation and intracellular tarfficking of the ABCA1 transporter. J Lipid Res. 2001; 42 1339-1345
35 Sharma P, Sabharanjak S, Mayor S. Endocytosis of lipid rafts: An identity crisis. Cell & Dev Biol. 2002; 13 205-214
36 Simons K, Ikonen E. Functional rafts in cell membranes. Nature. 1997; 387 569-572
37 Simons K, Ikonen E. How cells handle cholesterol. Science. 2000; 290 1721-1726
38 Simons M, Keller P, Destrooper B, Beyreuther K, Dotti C G, Simons K. Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. Proc Natl Acad Sci USA. 1998; 95 6460-6464
39 Singh I N, Sorrentino G, Kanfer J N. Activation of LA-N-2 cell phospholipase D by amyloid beta protein (25 - 35). Neurochem Res. 1998; 23 1225-1232
40 Sparks D L. Coronary artery disease, hypertension, apoE, and cholesterol: A link to Alzheimer's disease?. Ann NY Acad Sci. 1997; 826 128-146
41 Sparks D L, Hunsaker III J C, Scheff S W, Kryscio R J, Henson J L, Markesbery W R. Cortical senile plaques in coronary artery disease, aging and Alzheimer's disease. Neurobiol Aging. 1990; 11 601-607
42 Sparks D L, Scheff S W, Hunsaker III J C, Liu H, Landers T, Gross D R. Induction of Alzheimer-like ß-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol. Exp Neurol. 1994; 126 88-94
43 Steinberg D. Low density lipoprotein oxidation and its pathobiological significance. J Biol Chem. 1997; 272 20963-20966
44 Tall A R, Wang N, Mucksavage P. Is it time to modify the reverse cholesterol transport model?. J Clin Invest. 2001; 108 1273-1275
45 Walter M, Reinecke H, Gerdes U, Nofer J-R, Höbbel G, Seedorf U, Assman G. Defective regulation of phosphatidylcholine-specific phospholipases C and D in a kindred with Tangier disease: Evidence for the involvement of phosphatidylcholine breakdown in HDL-mediated cholesterol efflux mechanisms. J Clin Invest. 1996; 98 2315-2323
46 Wang L, Schuster G U, Hultenby K, Zhang Q, Andersson S, Gustafsson J-A. Liver X receptors in the central nervous system: From lipid homeostasis to neuronal degeneration. Proc Natl Acad Sci USA. 2002; 99 13878-13883
47 Winkler K, Scharnagl H, Tisljar U, Hoschützky H, Friedrich I, Hoffmann M M, Hüttinger M, Wieland H, März W. Competition of Aß amyloid peptide and apolipoprotein E for receptor-mediated endocytosis. J Lipid Res. 1999; 40 447-455
48 Wollmer M A, Streffer J R, Lütjohann D, Tsolaki M, Iakovidou V, Hegi T, Pasch T, Jung H H, Bergmann von K, Nitsch R M, Hock C, Papassotiropoulos A. ABCA1 modulates CSF cholesterol levels and influences the age at onset of Alzheimer's disease. Neurobiol Aging. 2002; 5757 1-6
49 Wood W G, Eckert G P, Igbavboa U, Müller W E. Amyloid beta-peptide interactions with membranes and cholesterol: Causes or causalties of Alzheimer's disease. Biochim Biophys Acta. 2003; 1610 281-290
50 Wu C, Butz S, Ying Ys, Anderson R GW. Tyrosine kinase receptors concentrated in Caveolae-like domains from neuronal plasma membrane. Journal of Biological Chemistry. 1997; 272 3554-3559
51 Yamaguchi H, Maat-Schieman M L, Duinen van S G, Prins F A, Neeskens P, Natte R, Roos R A. Amyloid beta protein (Abeta) starts to deposit as plasma membrane-bound form in diffuse plaques of brain from hereditary cerebral hemorrhage with amyloidosis-Dutch type, Alzheimer disease and nondemented aged subjects. J Neuropathol Exp Neurol. 2000; 59 723-732
52 Yanagisawa K. Cholesterol and pathological processes in Alzheimer's disease. J Neurosci Res. 2002; 70 361-366
53 Yang D S, Small D H, Seydel U, Smith J D, Hallmayer J, Gandy S E, Martins R N. Apolipoprotein E promotes the binding and uptake of ß-amyloid into Chinese hamster ovary cells in an isoform-specific manner. Neuroscience. 1999; 90 1217-1226
54 Yao Z X, Papadopoulos V. Function of beta-amyloid in cholesterol transport: a lead to neurotoxicity. FASEB J. 2002; 16 U184-198

W. Gibson Wood, Ph.D.

GRECC 11G, VA Medical Center

One Veterans Drive

Minneapolis, MN, 55417

Telefon: 612-467-3303

Fax: 612-725-2051

eMail: woodx002@umn.edu