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Planta Med 2003; 69(9): 826-830
DOI: 10.1055/s-2003-43219
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

Constituents from the Stems of Goniothalamus griffithii

Qing Mu1, 3 , Wei Dong Tang2 , Ruo Yan Liu4 , Chao Ming Li1 , Li Guang Lou2 , Han Dong Sun1 , Chang Qi Hu3
  • 1Phytochemistry Laboratory, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
  • 2Shanghai Institute of Medical Material, the Center of Life Sciences in Shanghai, Chinese Academy of Sciences, Shanghai, P. R. China
  • 3School of Pharmacy, Fudan University, Shanghai, P. R. China
  • 4Present address: Gejiu Chinese Traditional Hospital, Yunnan Province, P. R. China
This work was supported by the National Science Foundation of China (Grant No. 39 770 089) and the Applied and Basic Research Foundation of Yunnan province (Grant No. 97B038q)
Further Information

Publication History

Received: January 8, 2003

Accepted: April 18, 2003

Publication Date:
04 November 2003 (online)

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Abstract

A new cyclopeptide, grifficyclocin A (1), and a new aporphine alkaloid, griffinin (2) were isolated together with two known styryllactones from the stems of Goniothalamus griffithii. Their structures were identified spectroscopically and chemically. Among them, the griffinin (2) was isolated as the enol form in two tautomers, and the two known styryllactones, goniothalamin (3) and 8-O-acetylgoniotriol (4), showed selective in vitro antitumor activities.

Key words

Goniothalamus griffithii - Annonaceae - cyclopeptide - grifficyclocin A - griffinin - styryllactone

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Dr. Qing Mu

Yi Xue Yuan Road 138

Box 254

Pharmacy School

Fudan University

Shanghai 200032

People’s Republic of China

Email: muqing2000@yahoo.com