Functional Magnetic Resonance Imaging in Pediatrics

M. Wilke; S. K. Holland; J. S. Myseros; V. J. Schmithorst; W. S. Ball

doi:10.1055/s-2003-43260

Neuropediatrics, Inhaltsverzeichnis

Neuropediatrics 2003; 34(5): 225-233
DOI: 10.1055/s-2003-43260

Review Article

Georg Thieme Verlag Stuttgart · New York

Functional Magnetic Resonance Imaging in Pediatrics

M. Wilke¹ ^, ² ^, ³ , S. K. Holland¹ , J. S. Myseros⁴ , V. J. Schmithorst¹ , W. S. Ball¹ Jr.

¹Imaging Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA
²Division of Psychiatry, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA
³Department of Pediatric Neurology and Developmental Medicine, Children's Hospital, University of Tübingen, Tübingen, Germany
⁴Division of Neurosurgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA

Abstract

Functional magnetic resonance imaging (fMRI) allows non-invasive assessment of human brain function in vivo by detecting blood flow differences. In this review, we want to illustrate the background and different aspects of performing functional magnetic resonance imaging (fMRI) in the pediatric age group. An overview over current and future applications of fMRI will be given, and typical problems, pitfalls, and benefits of doing fMRI in the pediatric age group are discussed. We conclude that fMRI can successfully be applied in children and holds great promise for both research and clinical purposes.

Key words

Functional imaging - language lateralization - surgical planning - brain mapping

Volltext

Referenzen

References

1 Abou-Khalil B, Schlaggar B L. Is it time to replace the Wada test?. Neurology. 2002; 59 160-161
2 Aguirre G K, D'Esposito M. Experimental designs for brain fMRI. Moonen CTW, Bandettini PA Functional MRI. Berlin, Heidelberg, New York; Springer Verlag 2000: 369-80
3 Altman N R, Bernal B. Brain activation in sedated children: Auditory and visual functional MR imaging. Radiology. 2001; 221 56-63
4 Ardekani B A, Bachman A H, Helpern J A. A quantitative comparison of motion detection algorithms in fMRI. Magn Reson Imaging. 2001; 19 959-963
5 Binder J R, Swanson S J, Hammeke T A, Morris G L, Mueller W M, Fischer M. et al . Determination of language dominance using functional MRI: a comparison with the Wada test. Neurology. 1996; 46 978-984
6 Bookheimer S. Functional MRI of language: New approaches to understanding the cortical organization of semantic processing. Annu Rev Neurosci. 2002; 25 151-188
7 Briellmann R S, Abbott D F, Caflisch U, Archer J S, Jackson G D. Brain reorganisation in cerebral palsy: A high-field functional MRI study. Neuropediatrics. 2002; 33 162-165
8 Burgund E D, Kang H C, Kelly J E, Buckner R L, Snyder A Z, Petersen S E. et al . The feasibility of a common stereotactic space for children and adults in fMRI studies of development. NeuroImage. 2002; 17 184-200
9 Byars A W, Holland S K, Strawsburg R H, Schmithorst V J, Dunn R S, Ball Jr W S. Practical aspects of conducting large-scale fMRI studies in children. J Child Neurol. 2002; 17 885-890
10 Chen R, Cohen L G, Hallett M. Nervous system reorganization following injury. Neuroscience. 2002; 111 761-773
11 Chen W, Ogawa S. Principles of BOLD functional MRI. Moonen CTW, Bandettini PA Functional MRI. Berlin, Heidelberg, New York; Springer Verlag 2000: 103-113
12 Desmond J E, Sum J M, Wagner A D, Demb J B, Shear P K, Glover G H. et al . Functional MRI measurement of language lateralization in Wada-tested patients. Brain. 1995; 118 1411-1419
13 Detre J A, Wang J. Technical aspects and utility of fMRI using BOLD and ASL. Clin Neurophysiol. 2002; 113 621-634
14 Di Salle F, Formisano E, Linden D E, Goebel R, Bonavita S, Pepino A. et al . Exploring brain function with magnetic resonance imaging. Eur J Radiol. 1999; 30 84-94
15 Dymarkowski S, Sunaert S, Van Oostende S, Van Hecke P, Wilms G, Demaerel P. et al . Functional MRI of the brain: Localisation of eloquent cortex in focal brain lesion therapy. Eur Radiol. 1998; 8 1573-1580
16 Frank Y, Pavlakis S G. Brain imaging in neurobehavioral disorders. Pediatr Neurol. 2001; 25 278-287
17 Friederici A D, Meyer M, von Cramon D Y. Auditory language comprehension: An event-related fMRI study on the processing of syntactic and lexical information. Brain Lang. 2000; 75 289-300
18 Gaillard W D, Hertz-Pannier L, Mott S H, Barnett A S, LeBihan D, Theodore W H. Functional anatomy of cognitive development: fMRI of verbal fluency in children and adults. Neurology. 2000; 54 180-185
19 Gaillard W D, Balsamo L, Xu B, Grandin C B, Braniecki S H, Papero P H. et al . Language dominance in partial epilepsy patients identified with an fMRI reading task. Neurology. 2002; 59 256-265
20 Golby A J, Poldrack R A, Illes J, Chen D, Desmond J E, Gabrieli J D. Memory lateralization in medial temporal lobe epilepsy assessed by functional MRI. Epilepsia. 2002; 43 855-863
21 Hale T S, Hariri A R, McCracken J T. Attention-deficit/hyperactivity disorder: Perspectives from neuroimaging. Ment Retard Dev Disabil Res Rev. 2000; 6 214-219
22 Hertz-Pannier L, Chiron C, Jambaque I, Renaux-Kieffer V, Van de Moortele P F, Delalande O. et al . Late plasticity for language in a child's non-dominant hemisphere: A pre- and post-surgery fMRI study. Brain. 2002; 125 361-372
23 Hertz-Pannier L, Gaillard W D, Mott S H, Cuenod C A, Bookheimer S Y, Weinstein S. et al . Noninvasive assessment of language dominance in children and adolescents with functional MRI: a preliminary study. Neurology. 1997; 48 1003-1012
24 Holland S K, Plante E, Byars A W, Strawsburg R H, Schmithorst V J, Ball Jr W S. Normal fMRI brain activation patterns in children performing a verb generation task. Neuroimage. 2001; 14 837-843
25 Holloway V, Gadian D G, Vargha-Khadem F, Porter D A, Boyd S G, Connelly A. The reorganization of sensorimotor function in children after hemispherectomy. A functional MRI and somatosensory evoked potential study. Brain. 2000; 123 2432-2444
26 Holodny A I, Schulder M, Liu W C, Wolko J, Maldjian J A, Kalnin A J. The effect of brain tumors on BOLD functional MR imaging activation in the adjacent motor cortex: Implications for image-guided neurosurgery. AJNR Am J Neuroradiol. 2000; 21 1415-1422
27 Howseman A M, Bowtell R W. Functional magnetic resonance imaging: imaging techniques and contrast mechanisms. Philos Trans R Soc Lond B Biol Sci. 1999; 354 1179-1194
28 Jack C R, Lee C C, Ward H A, Riederer S J. The role of functional MRI in planning perirolandic surgery. Moonen CTW, Bandettini PA Functional MRI. Berlin, Heidelberg, New York; Springer Verlag 2000: 539-550
29 Jager L, Werhahn K J, Hoffmann A, Berthold S, Scholz V, Weber J. et al . Focal epileptiform activity in the brain: Detection with spike-related functional MR imaging - preliminary results. Radiology. 2002; 223 860-869
30 Jezzard P, Clare S. Sources of distortion in functional MRI data. Hum Brain Mapp. 1999; 8 80-85
31 Kaplan A M, Bandy D J, Manwaring K H, Chen K, Lawson M A, Moss S D. et al . Functional brain mapping using positron emission tomography scanning in preoperative neurosurgical planning for pediatric brain tumors. J Neurosurg. 1999; 91 797-803
32 Krings T, Erberich S G, Roessler F, Reul J, Thron A. MR blood oxygenation level-dependent signal differences in parenchymal and large draining vessels: Implications for functional MR imaging. AJNR Am J Neuroradiol. 1999; 20 1907-1914
33 Kruger G, Kastrup A, Glover G H. Neuroimaging at 1. 5 T and 3. 0 T: Comparison of oxygenation-sensitive magnetic resonance imaging. Magn Reson Med. 2001; 45 595-604
34 Lauritzen M. Relationship of spikes, synaptic activity, and local changes of cerebral blood flow. J Cereb Blood Flow Metab. 2001; 21 1367-1383
35 Logothetis N K. The neural basis of the blood-oxygen-level-dependent functional magnetic resonance imaging signal. Philos Trans R Soc Lond B Biol Sci. 2002; 357 1003-1037
36 Luna B, Sweeney J A. Studies of brain and cognitive maturation through childhood and adolescence: a strategy for testing neurodevelopmental hypotheses. Schizophr Bull. 2001; 27 443-455
37 Magistretti P J, Pellerin L. Cellular mechanisms of brain energy metabolism and their relevance to functional brain imaging. Phil Trans R Soc Lond B. 1999; 354 1155-1163
38 Martin E, Joeri P, Loenneker T, Ekatodramis D, Vitacco D, Hennig J. et al . Visual processing in infants and children studied using functional MRI. Pediatr Res. 1999; 46 135-140
39 McKeown M J, Sejnowski T J. Independent component analysis of fMRI data: Examining the assumptions. Hum Brain Mapp. 1998; 6 368-372
40 Menon R S. Postacquisition suppression of large-vessel BOLD signals in high-resolution fMRI. Magn Reson Med. 2002; 47 1-9
41 Moses P, Stiles J. The lesion methodology: Contrasting views from adult and child studies. Dev Psychobiol. 2002; 40 266-277
42 National institutes of Mental Health . National Institute of Mental Health research roundtable on prepubertal bipolar disorder. J Am Acad Child Adolesc Psychiatry. 2000; 40 871-878
43 Ogawa S, Tank D W, Menon R, Ellermann J M, Kim S G, Merkle H. et al . Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging. Proc Natl Acad Sci USA. 1992; 89 5951-5955
44 Oller D K, Eilers R E, Neal A R, Cobo-Lewis A B. Late onset canonical babbling: a possible early marker of abnormal development. Am J Ment Retard. 1998; 103 249-263
45 Rijntjes M, Weiller C. Recovery of motor and language abilities after stroke: the contribution of functional imaging. Prog Neurobiol. 2002; 66 109-122
46 Rivkin M J. Developmental neuroimaging of children using magnetic resonance techniques. Ment Retard Dev Disabil Res Rev. 2000; 6 68-80
47 Roux F E, Boulanouar K, Ranjeva J P, Tremoulet M, Henry P, Manelfe C. et al . Usefulness of motor functional MRI correlated to cortical mapping in Rolandic low-grade astrocytomas. Acta Neurochir (Wien). 1999; 141 71-79
48 Rubia K, Overmeyer S, Taylor E, Brammer M, Williams S C, Simmons A. et al . Hypofrontality in attention deficit hyperactivity disorder during higher-order motor control: a study with functional MRI. Am J Psychiatry. 1999; 156 891-896
49 Schad L R. Improved target volume characterization in stereotactic treatment planning of brain lesions by using high-resolution BOLD MR-venography. NMR Biomed. 2001; 14 478-483
50 Schapiro M B, Holland S K, Schmithorst V J, Wilke M, Weber Byars A, Strawsburg R. Functional magnetic resonance imaging (fMRI) brain activation increases with age in children performing a finger tapping task. Ann Neurol. 2002; 52 S135
51 Schlaggar B L, Brown T T, Lugar H M, Visscher K M, Miezin F M, Petersen S E. Functional neuroanatomical differences between adults and school-age children in the processing of single words. Science. 2002; 296 1476-1479
52 Schmithorst V J, Dardzinski B J, Holland S K. Simultaneous correction of ghost and geometric distortion artifacts in EPI using a multiecho reference scan. IEEE Trans Med Imaging. 2001; 20 535-539
53 Spreer J, Arnold S, Quiske A, Wohlfarth R, Ziyeh S, Altenmuller D. et al . Determination of hemisphere dominance for language: Comparison of frontal and temporal fMRI activation with intracarotid amytal testing. Neuroradiology. 2002; 44 467-474
54 Staudt M, Grodd W, Gerloff C, Erb M, Stitz J, Krägeloh-Mann I. Two types of ipsilateral reorganization in congenital hemiparesis: A TMS and fMRI study. Brain. 2002; 125 2222-2237
55 Staudt M, Lidzba K, Grodd W, Wildgruber D, Erb M, Krägeloh-Mann I. Right-hemispheric organization of language following early left-sided brain lesions: functional MRI topography. Neuroimage. 2002; 16 954-967
56 Szaflarski J P, Holland S K, Shear P K, Schmithorst V J, Strakowski S M. et al . Using different fMRI language and memory tasks in healthy adults at 3 T. Epilepsia. 2002; 43 (Suppl 8) 55
57 Thomas K M, Casey B J. Functional MRI in pediatrics. Moonen CTW, Bandettini PA Functional MRI. Berlin, Heidelberg, New York; Springer Verlag 2000: 513-524
58 Vaidya C J, Austin G, Kirkorian G, Ridlehuber H W, Desmond J E, Glover G H. et al . Selective effects of methylphenidate in attention deficit hyperactivity disorder: a functional magnetic resonance study. Proc Natl Acad Sci USA. 1998; 95 14494-14499
59 Wilke M, Schmithorst V J, Holland S K. Assessment of spatial normalization of whole-brain magnetic resonance images in children. Hum Brain Mapp. 2002; 17 48-60
60 Wilke M, Schmithorst V J, Weber A M, Strawsburg R H, Holland S K. Changes in the language lateralization index with age as detected by functional MRI in normal children. Neuropediatrics. 2002; 33 A4
61 Yetkin F Z, Papke R A, Mark L P, Daniels D L, Mueller W M, Haughton V M. Location of the sensorimotor cortex: functional and conventional MR compared. AJNR Am J Neuroradiol. 1995; 16 2109-2113

M. D. Marko Wilke

Department of Pediatric Neurology and Developmental Medicine, Children's Hospital, University of Tübingen

Hoppe‐Seyler-Straße 3

72076 Tübingen

Germany

eMail: Marko.Wilke@med.uni-tuebingen.de